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PURPOSE We have previously shown that von Hippel-Lindau (VHL) regulates ubiquitylation and proline 1465 hydroxylation of the large subunit of RNA polymerase II, Rpb1, in human renal clear cell carcinoma (RCC) cell lines. Here, our goal was to determine the effect of this VHL function and the status of P1465 hydroxylation in human RCC tumors. EXPERIMENTAL(More)
—This paper presents a novel instruction cell-based re-configurable computing architecture for low-power applications, thereafter referred to as the reconfigurable instruction cell array (RICA). For the development of the RICA, a top-down software driven approach was taken and revealed as one of the key design decisions for a flexible, easy to program,(More)
Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct(More)
Von Hippel-Lindau tumor suppressor (VHL) is lost in the majority of clear cell renal cell carcinomas (ccRCC). Folliculin (FLCN) is a tumor suppressor whose function is lost in Birt-Hogg-Dubé syndrome (BHD), a disorder characterized by renal cancer of multiple histological types including clear cell carcinoma, cutaneous fibrofolliculoma, and pneumothorax.(More)
A .~yste!ii I f i d d e s i p frrrliiework for FPCA-based DSP desigi~ is presented. The design pow ictilizes Sysfein Ceiiemfor, U svsfeni leoel fool developed by Xiliru, and 1i:il.s ir ro (I,I "ill-house'' archirerfurul synrhesis fool, IRIS. Wliilsf Svsfeiir Cellerafor allows FPCA-hosed Ii~fellect~tal Properq (IPJ cores fo be bicorporared info the desig,~(More)
Human renal clear cell carcinoma (RCC) is frequently associated with loss of the von Hippel-Lindau (VHL) tumor suppressor (pVHL), which inhibits ubiquitylation and degradation of the alpha subunits of hypoxia-inducible transcription factor. pVHL also ubiquitylates the large subunit of RNA polymerase II, Rpb1, phosphorylated on serine 5 (Ser5) within the(More)
Results are presented that explore the possibility of organocyanide compounds in wastewater contributing to elevated cyanide levels in the chlorinated effluents of publicly owned treatment works. Four model compounds, acetonitrile, amygdalin, cyanocobalamin, and 2-acetoxy-3-butenenitrile, were selected and tested with varying chlorine dosages for release of(More)
Chlorine dioxide (CD) gas has been used as a fumigant in the disinfection of biosafety laboratories. In this study, some experiments were conducted to assess the inactivation of spores inoculated on six materials [stainless steel (SS), painted steel (PS), polyvinyl chlorid (PVC), polyurethane (PU), glass (GS), and cotton cloth (CC)] by CD gas. The main aims(More)
Copper complexes of chitosan have been synthesized. Complexes with different copper to chitosan ratios were tested in vitro as potential antitumor agents with 293 cells and HeLa cells. At the ratio of 0.11 mol copper per one chitosan residue, the complex exhibited a higher antitumor activity and less toxicity than other copper-chitosan complexes tested. In(More)