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Von Hippel-Lindau tumor suppressor (VHL) is lost in the majority of clear cell renal cell carcinomas (ccRCC). Folliculin (FLCN) is a tumor suppressor whose function is lost in Birt-Hogg-Dubé syndrome (BHD), a disorder characterized by renal cancer of multiple histological types including clear cell carcinoma, cutaneous fibrofolliculoma, and pneumothorax.(More)
This paper presents a novel instruction cell-based reconfigurable computing architecture for low-power applications, thereafter referred to as the reconfigurable instruction cell array (RICA). For the development of the RICA, a top-down software driven approach was taken and revealed as one of the key design decisions for a flexible, easy to program,(More)
Human renal clear cell carcinoma (RCC) is frequently associated with loss of the von Hippel-Lindau (VHL) tumor suppressor (pVHL), which inhibits ubiquitylation and degradation of the alpha subunits of hypoxia-inducible transcription factor. pVHL also ubiquitylates the large subunit of RNA polymerase II, Rpb1, phosphorylated on serine 5 (Ser5) within the(More)
This paper presents a new Baseline Profile compliant h.264 decoder implementation specifically tailored for an ANSI-C programmable, dynamically reconfigurable, instruction cell based architecture which has recently been developed [10]. We use the ffmpeg libavcodec library as the basis for our decoder and identify the most processor intensive functions.(More)
A .~yste!ii I f i d d e s i p frrrliiework for FPCA-based DSP desigi~ is presented. The design pow ictilizes Sysfein Ceiiemfor, U svsfeni leoel fool developed by Xil i ru , and 1i:il.s ir ro (I,I "ill-house'' archirerfurul synrhesis fool, IRIS. Wliilsf Svsfeiir Cellerafor allows FPCA-hosed Ii~fellect~tal Properq ( IPJ cores fo be bicorporared info the(More)
Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct(More)
OBJECTIVE To design and rapidly evaluate a TaqMan assay for detecting influenza A viruses. METHODS The probe and the primers of the assay were designed with the software packages of DNA Star and Primer Premier 5.0. Their specificity and conservation were verified through Blast in GenBank and electronic hybridization. The assay's sensitivity was compared(More)
Multi-core architectures are increasingly being adopted in the design of emerging complex embedded systems. Key issues of designing such systems are on-chip interconnects, memory architecture, and task mapping and scheduling. This paper presents an integer linear programming formulation for the task mapping and scheduling problem. The technique incorporates(More)
Transcriptomic analyses have revealed an unexpected complexity in the eukaryote transcriptome, which includes not only protein-coding transcripts but also an expanding catalog of noncoding RNAs (ncRNAs). Diverse coding and noncoding RNAs (ncRNAs) perform functions through interaction with each other in various cellular processes. In this project, we have(More)