Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria.
- C. Brett, Ying Wei, M. Donowitz, R. Rao
- BiologyAmerican Journal of Physiology - Cell Physiology
- 1 May 2002
The results suggest that, like its homologs in yeast and plants, NHE6 is an endosomal Na(+)/H(+) exchanger that may regulate intravesicular pH and volume and contribute to lysosomal biogenesis.
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei
- Yan-Zi Wen, Lingling Zheng, Z. Lun
- BiologyProceedings of the National Academy of Sciences
- 29 April 2011
It is shown that these pseudogene-derived siRNAs suppress gene expression through RNA interference and provide insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
Arginine Methylation of hnRNP A2 Does Not Directly Govern Its Subcellular Localization
- L. Friend, M. Landsberg, A. Nouwens, Ying Wei, J. Rothnagel, Ross Smith
- Biology, ChemistryPLoS ONE
- 30 September 2013
The results suggest an alternative role for post-translational arginine methylation of hnRNPs and offer further evidence that the hnRNP A/B paralogs are not functionally redundant.
Molecular epidemiology of trypanosoma evansi and T. Equiperdum and atypical human infection by animal trypanosomes
- Ying Wei, Yan-Zi Wen, M. Desquesnes, Z. Lun
Different models of evolution are presented and evaluated and the important question of the potential of these species to become human infective is explored, to improve the understanding of the genetic and evolutionary relationships.
Induction of vacuolar Ca 2-ATPase and H / Ca 2 exchange activity in yeast mutants lacking Pmr 1 , the Golgi Ca 2-ATPase
The results, together with measurements of polypeptide expression levels and promoter: :reporter gene activity, show that the Golgi Ca2-ATPase, Pmr1, is the major Ca 2 pump under normal growth conditions.
Distinct Roles of a Mitogen-Activated Protein Kinase in Cytokinesis between Different Life Cycle Forms of Trypanosoma brucei
It is shown that a MAP kinase homolog from Trypanosoma brucei plays distinct roles in cytokinesis in two life cycle forms of T. Brucei, and the involvement of the TbMAPK6-mediated pathway in regulating cytokineis in trypanosomes is demonstrated and suggested.
Cytochrome b 560 ( QPs 1 ) of Mitochondrial Succinate-Ubiquinone Reductase
- Linda P. C. Yu, Ying Wei, S. Usui, Chang-an Yu
- Biology, Chemistry
Although the apparent molecular weight of QPsl, estimated by high resolution SDS-polyacrylamide gel electrophoresis, is 11,000, the existence of a presequence was ruled out by mass spectrometric analysis of protein fragments, indicating that QPSl is a very hydrophobic protein.
UFMylation: A Unique & Fashionable Modification for Life
- Ying Wei, Xingzhi Xu
- Biology, ChemistryGenomics, Proteomics & Bioinformatics
- 20 May 2016
Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
- Xiangxi Xu, Yuan Cai, A. Mazar
- BiologyPLoS ONE
- 21 January 2014
A new functional epitope on uPAR involved in tumor progression is revealed and a previously unrecognized strategy for the therapeutic targeting of uPAR is demonstrated.
Centrin3 in trypanosomes maintains the stability of a flagellar inner-arm dynein for cell motility
- Ying Wei, Huiqing Hu, Z. Lun, Ziyin Li
- BiologyNature Communications
- 31 May 2014
A role is identified for one of five centrin proteins, TbCentrin3, in stabilizing the assembly of a dynein motor essential for flagellar motility in cells of Trypanosoma brucei.