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While the treemap is a popular method for visualizing hierarchical data, it is often difficult for users to track layout and attribute changes when the data evolve over time. When viewing the treemaps side by side or back and forth, there exist several problems that can prevent viewers from performing effective comparisons. Those problems include abrupt(More)
The treemap is one of the most popular methods for visualizing hierarchical data. When a treemap contains a large number of items, inspecting or comparing a few selected items in a greater level of detail becomes very challenging. In this paper, we present a seamless multi-focus and context technique, called Balloon Focus, that allows the user to smoothly(More)
The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. We found that DNA-dependent protein kinase catalytic subunit (DNA-PKcs)(More)
BACKGROUND Insulin-like growth factors (IGFs) are implicated in many normal physiological processes and pathological states, including cancer. For large consortia projects, it may be necessary to make comparisons among studies with different specimens that were not collected specifically to optimize the measurement of IGFs. OBJECTIVE This study aimed to(More)
MicroRNA (miR)-499 rs3746444 polymorphisms may participate in the pathogenesis of autoimmune diseases, but the results remain conflicting. We further investigated this association using a meta-analysis. We conducted a retrieval of studies and obtained the eligible studies if they met inclusion criteria. Two researchers independently extracted the data from(More)
A diverse library of pre-fractionated plant extracts, generated by an automated high-throughput system, was tested using an in vitro anti-malarial screening platform to identify known or new natural products for lead development. The platform identifies hits on the basis of in vitro growth inhibition of Plasmodium falciparum and counter-screens for(More)
The present study examined the mechanisms of high mobility group box 1 (HMGB1)-induced cell migration in human cutaneous squamous cell carcinoma (CSCC) SCC13 cells. Western blotting, a chemotaxis assay and ELISA were performed to analyze HMGB1 level in SCC13 cells and its ability to regulate tumor metastasis. The results demonstrated a significantly higher(More)
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