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—A 128-bit, 1.6 pJ/bit, 96% stable chip ID generation circuit utilizing process variations is designed in a 0.13 m CMOS process. The circuit consumes 162 nW from a 1 V supply at low readout frequencies and 1.6 W at 1 Mb/s. Cross-coupled logic gates were employed to simultaneously generate, amplify, and digitize the random circuit offset to create a stable(More)
Many integrated circuit applications require a unique identification number (ID) on each die that can be read anytime during the lifetime of the chip. A robust read-only ID is important for labeling RFID tags, addressing low-power wireless sensor nodes, IC process quality control, and secure documentation. Traditional methods of writing addresses into ROMs(More)
TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated through transcriptional functions of Smads. A key step in TGFbeta signaling is ligand-induced phosphorylation of receptor-activated Smads (R-Smads) catalyzed by the(More)
Early full-term pregnancy is one of the most effective natural protections against breast cancer. To investigate this effect, we have characterized the global gene expression and epigenetic profiles of multiple cell types from normal breast tissue of nulliparous and parous women and carriers of BRCA1 or BRCA2 mutations. We found significant differences in(More)
  • Susana A. Godinho, Remigio Picone, Mithila Burute, Regina Dagher, Ying Su, Cheuk T. Leung +4 others
  • 2014
Centrosome amplification has long been recognized as a feature of human tumours; however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequency of centrosome amplification, particularly in more(More)
A reaction-diffusion population model with a general time-delayed growth rate per capita is considered. From a careful analysis of the characteristic equation, the stability of the positive steady state solution and the existence of supercritical Hopf bifurcation from the positive steady state solution are obtained via the implicit function theorem, where(More)
Breast cancer risk is highly modifiable by diet; however, mechanisms underlying dietary protection against mammary tumorigenesis remain poorly understood. A proportion of breast carcinomas is associated with deregulation of beta-catenin stability and amplification of c-Myc expression. We recently showed that dietary exposure to the soy isoflavone genistein(More)
The dynamics of a diffusive Nicholson's blowflies equation with a finite delay and Dirichlet boundary condition have been investigated in this paper. The occurrence of steady state bifurcation with the changes of parameter is proved by applying phase plane ideas. The existence of Hopf bifurcation at the positive equilibrium with the changes of specify(More)