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Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots
TLDR
The presence of intestinal bacteria is demonstrated to play an important role in the gastrointestinal metabolism of WESB, and the pharmacological effects of Scutellaria baicalensis may be dependent on the intestinal bacteria metabolism.
Effects of broad-spectrum antibiotics on the metabolism and pharmacokinetics of ginsenoside Rb1: a study on rats׳ gut microflora influenced by lincomycin.
TLDR
It is demonstrated that consumption of lincomycin could lead to the formation of specific metabolites and pharmacokinetic changes of ginsenoside Rb1 in the gut, attributed to alterations in metabolic activities of intestinal bacteria.
The Metabolism of Polysaccharide from Atractylodes macrocephala Koidz and Its Effect on Intestinal Microflora
TLDR
It is concluded that PAM can significantly improve disordered intestinal flora and may be used as an oral adjuvant to regulate intestinal flora.
In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites
TLDR
The metabolism of Forsythoside A by human fecal bacteria to clarify the relationship between its intestinal metabolism and its pharmacological activities was investigated, and the metabolites showed higher biological activity than FTA, especially HT and DCA.
Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract
TLDR
It was shown that the highest concentration was achieved in the small intestine and feces clearance was shown to be the dominant elimination pathway of the lactones in Radix Inulae.
Purification, Characterization and Antitumor Activities of a New Protein from Syngnathus acus, an Officinal Marine Fish
TLDR
Flow cytometry, morphologic assessment and comet assay revealed that Syngnathusin could induce apoptosis in A549 and CCRF-CEM cells and strongly cooperated with MTX, and may be developed as a novel, selective and effective antineoplastic agent.
Gut Microbial Diversity in Rat Model Induced by Rhubarb
TLDR
The enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) method was utilized to detect changes in bacterial diversity in feces and the bowel mucosa associated with this model and found that the fecal microbial composition did not correspond to the bowel bacteria mix.
Intestinal microflora molecular markers of spleen-deficient rats and evaluation of traditional Chinese drugs.
TLDR
Both fingerprint analysis and identified marker can showPi-deficiency in rats and its difference after treatment, and the identified molecular marker may be applied in screening for the active compounds both in relative traditional Chinese drugs and in pharmacodynamic study of Pi-deficient in rats.
Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration
Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix. Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time. As a result, nine
Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro.
TLDR
This study investigates the immunomodulatory mechanism of S-3-1, a homogeneous polysaccharide purified from SJZD with immune-enhancement activity, by investigating its effects on human intestinal microbes and short chain fatty acids.
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