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Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive(More)
Traditional association rules mining cannot meet the demands arising from some real applications. By considering the different values of individual items as utilities, utility mining focuses on identifying the itemsets with high utilities. In this paper, we present a Two-Phase algorithm to efficiently prune down the number of candidates and precisely obtain(More)
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarate (2-HG), respectively. Here we demonstrate that 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the(More)
In order to improve the retrieval accuracy of content-based image retrieval systems, research focus has been shifted from designing sophisticated low-level feature extraction algorithms to reducing the ‘semantic gap’ between the visual features and the richness of human semantics. This paper attempts to provide a comprehensive survey of the recent technical(More)
* Different portions of tree root systems play distinct functional roles, yet precisely how to distinguish roots of different functions within the branching fine-root system is unclear. * Here, anatomy and mycorrhizal colonization was examined by branch order in 23 Chinese temperate tree species of both angiosperms and gymnosperms forming ectomycorrhizal(More)
In order to accumulate the foundational information about the nutrients related to 7 species of desert plants, chemical and instrumental methods for determination were used and quantitative results were obtained as follows (%, in dry mass): calcium 0.73-3.89, phosphorus 0.043-0.34, selenium 0.026-2.8, protein 3.38-13.92, lipid 3.97-15.03, total sugar(More)
Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung(More)
Regulatory compliance of business operations is a critical problem for enterprises. As enterprises increasingly use business process management systems to automate their business processes, technologies to automatically check compliance of process models against compliance rules are becoming important. In this paper, we present a method for improving the(More)
Consumers’ purchase decisions can be influenced by others’ opinions, i.e., word-of-mouth (WOM), and/or others’ actions, i.e., observational learning. While information technologies are creating increasing opportunities for firms to facilitate/manage these two types of social interaction, researchers so far have encountered difficulty in disentangling their(More)