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Cucumber is an economically important crop as well as a model system for sex determination studies and plant vascular biology. Here we report the draft genome sequence of Cucumis sativus var. sativus L., assembled using a novel combination of traditional Sanger and next-generation Illumina GA sequencing technologies to obtain 72.2-fold genome coverage. The(More)
Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031(More)
Viral infection triggers activation of transcription factors such as NF-kappaB and IRF3, which collaborate to induce type I interferons (IFNs) and elicit innate antiviral response. Here, we identified MITA as a critical mediator of virus-triggered type I IFN signaling by expression cloning. Overexpression of MITA activated IRF3, whereas knockdown of MITA(More)
The initiator caspase Dronc is the only Drosophila caspase that contains a caspase activation and recruitment domain (CARD). Although Dronc has been implicated as an important effector of apoptosis, the genetic function of dronc in normal development is unclear because dronc mutants have not been available. In an EMS mutagenesis screen, we isolated four(More)
The KDD-Cup 2005 Competition was held in conjunction with the Eleventh ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. The task of the KDD-Cup 2005 competition was to classify 800,000 internet user search queries into 67 predefined categories. This task is easy to understand, but the lack of straightforward training set,(More)
We provide an analysis to the performance of Optical Orthogonal Codes(OOC) in an Optical Code Division Multiple Access(CDMA) network by considering the probability distribution of the interference patterns. We show that the actual performance is close to a previous estimate. We also consider a less structured temporal code in which the code words are(More)
In this demo, we present the Microsoft Complex Event Processing (CEP) Server, Microsoft CEP for short. Microsoft CEP is an event stream processing system featured by its declarative query language and its multiple consistency levels of stream query processing. Query composability, query fusing, and operator sharing are key features in the Microsoft CEP(More)
p21(Cip1/WAF1) (p21), a p53-inducible protein, is a critical regulator of cell cycle and cell survival. p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear antigen and cyclin A/E-CDK2 complexes. Recently, p21 has also been shown to be a positive regulator of cell cycle progression as p21 is necessary for the assembly and(More)
Understanding goals and preferences behind a user's online activities can greatly help information providers, such as search engine and E-Commerce web sites, to personalize contents and thus improve user satisfaction. Understanding a user's intention could also provide other business advantages to information providers. For example, information providers(More)
Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific(More)