Ying-Jie Zhang

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OBJECTIVE The aim of the study is to investigate the prevalence rate of restless legs syndrome (RLS) in elderly Chinese people over 50 years of age in an urban suburb of Shanghai by a community-based study. METHODS A 3-step survey was adopted including two telephone-based interviews and one face-to-face interview. We used questions based on four(More)
Compounding evidence suggests that alpha-synuclein (SNCA) plays an important role in the pathogenesis of Parkinson's disease (PD) by inducing neurotoxicity. Mitochondria are highly dynamic organelles that undergo fusion and fission processes, the imbalance of which has been viewed as a key trigger for PD. However, the underlying relationship between SNCA(More)
Increasing evidence suggests that microglial activation may participate in the aetiology and pathogenesis of Parkinson's disease (PD). CD200-CD200R signalling has been shown to be critical for restraining microglial activation. We have previously shown that expression of CD200R in monocyte-derived macrophages, induced by various stimuli, is impaired in PD(More)
Parkinson’s disease (PD) is pathologically characterized by the presence of α-synuclein positive intracytoplasmic inclusions. The missense mutation, A53T α-synuclein is closely related to hereditary, early-onset PD. Accumulating evidences suggest that pathological accumulation of A53T α-synuclein protein will perturb itself to be efficiently and normally(More)
ETHNOPHARMACOLOGICAL RELEVANCE Astragaloside IV (As IV) is one of the main effective components isolated from the traditional Chinese medical herb Astragalus membranaceus. The protective effect of Astragalus membranaceus on myocardial hypertrophy has been extensively proved. To test the hypothesis that Astragaloside IV can ameliorate the myocardial(More)
The introduction of genes associated with the fate of dopaminergic (DA) neurons may help to facilitate the differentiation of embryonic stem cells (ESC) to DA neurons. Here we used lentiviral vectors to drive lmx1b, a key transcription factor of dopaminergic neurons development, expression in ESC. Tyrosine hydroxylase-positive neurons were increased from(More)
Gene frequency, polymorphism information contents, number of effective alleles, heterozygosity and genetic distances were studied in Boer goat, Taihang goat and Hebei dairy goat using four microsatellite markers (OarFCB11, OarAE101, McM218, McM38). The crossing effects on Hebei dairy goat and Taihang goat with Boer goat were tested. The results indicated(More)
Program slicing is a popular but imprecise technique for identifying which parts of a program affect or are affected by a particular value. A major reason for this imprecision is that slicing reports all program statements possibly affected by a value, regardless of how relevant to that value they really are. In this paper, we introduce quantitative slicing(More)
Sensitivity analysis is used in many fields to determine how different parts of a system respond to variations in stimuli. Softwaredevelopment tasks, such as change-impact analysis, can also benefit from sensitivity analysis. In this paper, we present SENSA, a novel dynamic-analysis technique and tool that uses sensitivity analysis and execution(More)
The minimal time a system needs to evolve from an initial state to its one orthogonal state is defined as the quantum speed limit time, which can be used to characterize the maximal speed of evolution of a quantum system. This is a fundamental question of quantum physics. We investigate the generic bound on the minimal evolution time of the open dynamical(More)