Ying-Jie Zhang

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BACKGROUND Increasing evidence suggests that microglial activation may participate in the aetiology and pathogenesis of Parkinson's disease (PD). CD200-CD200R signalling has been shown to be critical for restraining microglial activation. We have previously shown that expression of CD200R in monocyte-derived macrophages, induced by various stimuli, is(More)
Parkinson’s disease (PD) is pathologically characterized by the presence of α-synuclein positive intracytoplasmic inclusions. The missense mutation, A53T α-synuclein is closely related to hereditary, early-onset PD. Accumulating evidences suggest that pathological accumulation of A53T α-synuclein protein will perturb itself to be efficiently and normally(More)
Compounding evidence suggests that alpha-synuclein (SNCA) plays an important role in the pathogenesis of Parkinson's disease (PD) by inducing neurotoxicity. Mitochondria are highly dynamic organelles that undergo fusion and fission processes, the imbalance of which has been viewed as a key trigger for PD. However, the underlying relationship between SNCA(More)
In this paper, some sharp inequalities for bounding the gamma function Γ(x) and the ratio of two gamma functions are established. From these, several known results are recovered , refined, extended and generalized simply and elegantly. In [4], it was proved that the function (1) f (x) = ln Γ(x + 1) x ln x is strictly increasing from (1, ∞) onto (1 − γ, 1),(More)
The minimal time a system needs to evolve from an initial state to its one orthogonal state is defined as the quantum speed limit time, which can be used to characterize the maximal speed of evolution of a quantum system. This is a fundamental question of quantum physics. We investigate the generic bound on the minimal evolution time of the open dynamical(More)
The introduction of genes associated with the fate of dopaminergic (DA) neurons may help to facilitate the differentiation of embryonic stem cells (ESC) to DA neurons. Here we used lentiviral vectors to drive lmx1b, a key transcription factor of dopaminergic neurons development, expression in ESC. Tyrosine hydroxylase-positive neurons were increased from(More)
This study aimed to evaluate the efficacy, toxicity and tolerability of simultaneous modulated accelerated radiation therapy (SMART)-intensity modulated radiotherapy (IMRT) plus cisplatin and 5-fluorouracil (5-FU) chemo-therapy for patients with advanced nasopharyngeal cancer (NPC). Forty-five patients with stage II-IV NPC, determined by the American Joint(More)
It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that(More)
We study the coherence trapping of a qubit correlated initially with a non-Markovian bath in a pure dephasing channel. By considering the initial qubit-bath correlation and the bath spectral density, we find that the initial qubit-bath correlation can lead to a more efficient coherence trapping than that of the initially separable qubit-bath state. The(More)
The clinical acute graft-versus-host disease (GvHD)-therapy of mesenchymal stem cells (MSCs) is not as satisfactory as expected. Secondary lymphoid organs (SLOs) are the major niches serve to initiate immune responses or induce tolerance. Our previous study showed that CCR7 guide murine MSC line C3H10T1/2 migrating to SLOs. In this study, CCR7 gene was(More)