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Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway
An innovative nano-enabled approach has been established to allow deliberate use of ICD to switch an immune deplete to an immune replete BC microenvironment, allowing further boosting of the response by coadministered IDO inhibitors or immune checkpoint blocking antibodies. Expand
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.
- J. Wong, Guozhi Tang, +36 authors L. Chen
- Chemistry, Medicine
- Journal of medicinal chemistry
- 12 October 2012
Herein, we describe the pharmacokinetic optimization of a series of class-selective histone deacetylase (HDAC) inhibitors and the subsequent identification of candidate predictive biomarkers of… Expand
Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer.
Improved drug delivery was accompanied by substantially improved efficacy, increased survival, and reduced bone marrow and GI toxicity compared to the free drug and Onivyde, and the Ir-silicasome appears to be promising as a treatment option for CRC in humans based on improved efficacy and the carrier's favorable safety profile. Expand
Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model.
The engineering of a biodegradable polymeric poly(lactic- co-glycolic acid) (PLGA) nanocarrier for the selective delivery of the murine allergen, ovalbumin (OVA), to the liver is demonstrated and it is shown that liver and LSEC targeting PLGA NPs could be used for therapy of allergic airway disease. Expand
Targeted drug delivery using iRGD peptide for solid cancer treatment.
- X. Liu, Jinhong Jiang, Ying Ji, J. Lu, Ryan Chan, Huan Meng
- Molecular systems design & engineering
- 11 October 2017
This focused review summarized the design and implementation strategy for iRGD-mediated tumor targeting, including the working principle of such peptide and discussion on patient-specific iR GD effect in vivo, commensurate with the level of key biomarker expression on tumor vasculature. Expand
Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid.
A nanoplatform from the supramolecular assembly of β-cyclodextrin grafted hyaluronic acid (HA) and phenylalanine based pseudo protein is developed to provide a promising platform for the delivery of hydrophobic chemotherapeutics to improve the bioavailability and efficiency. Expand
Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo.
A multi-arm PRX nanocarrier platform, designed for protective nucleic acid encapsulation, augmented biodistribution and PK, and suitable for intravenous (IV) administration is developed, which significantly enhanced circulatory half-life and PK profile compared to the linear PRX. Expand
Enhanced MHC-I antigen presentation from the delivery of ovalbumin by light-facilitated biodegradable poly(ester amide)s nanoparticles.
The optimized stimulation of MHC-I response demonstrated the potency of this light-facilitated nano-platform for CD8 T cell-inducing vaccination. Expand
Biodegradable nanocomplex from hyaluronic acid and arginine based poly(ester amide)s as the delivery vehicles for improved photodynamic therapy of multidrug resistant tumor cells: An in vitro study…
- Ying Ji, Jihui Zhao, C. Chu
- Materials Science, Medicine
- Journal of biomedical materials research. Part A
- 1 May 2017
A biodegradable nanocomplex HA-Arg-PEA from hyaluronic acid and arginine based poly(ester amide)s (Arg- PEA) as the nanocarrier for chlorin e6 (Ce6) enhanced the tumor-specific endocytosis mediated by the overexpression of CD44 receptor and enabled the intracellular delivery of Ce6. Expand
A light-facilitated drug delivery system from a pseudo-protein/hyaluronic acid nanocomplex with improved anti-tumor effects.
The in vivo results suggested that the conjugation of AlPCs2a in the nanocomplex enabled the consistent and preferential accumulation of both doxorubicin and AlPcS 2a in tumor sites, and can hold great potential to achieve spatio-temporally controllable anti-tumor effects. Expand