Ying-Hua Chang

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The pathophysiology of heart failure (HF) is diverse, owing to multiple etiologies and aberrations in a number of cellular processes. Therefore, it is essential to understand how defects in the molecular pathways that mediate cellular responses to internal and external stressors function as a system to drive the HF phenotype. Mass spectrometry (MS)-based(More)
This study proposes a novel, efficient means of encoding genetic algorithms to solve the generalized plant allocation problem. The problem relates to allocating products across plants to minimize a total cost function. The proposed encoding method can reduce the search space of solutions more efficiently than the penalty encoding method does. The new(More)
Tissue inhibitor metalloproteinase-1 (TIMP-1) is clinically associated with a poor prognosis for various cancers, but the roles of TIMP-1 in lung cancer metastasis are controversial. Our previous secretomic study revealed that TIMP-1 is highly abundant in high invasiveness cells of lung adenocarcinoma. In the current study, TIMP-1 abundances in primary lung(More)
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