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Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles.
TLDR
It is shown that the former particles penetrate the plasma membrane without bilayer disruption, whereas the latter are mostly trapped in endosomes, offering a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules. Expand
Adenovirus-Mediated Overexpression of O-GlcNAcase Improves Contractile Function in the Diabetic Heart
TLDR
It is concluded that excess O-GlcNAcylation in the diabetic heart contributes to cardiac dysfunction, and reducing this excess cellular O-GCA has beneficial effects on calcium handling and diabetic cardiac function. Expand
Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose*
TLDR
Exposure to high glucose increases mitochondrial protein O-GlcNAcylation, which in turn contributes to impaired mitochondrial function, and it is concluded that specific mitochondrial proteins of cardiac myocytes are O- glncNAcylated and that exposed mitochondrial function is impaired. Expand
Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.
TLDR
The synbiotic combination of RS and B.lactis significantly protects against the development of CRC in the rat-azoxymethane model and seems likely to be a superior preventive strategy to prebiotic alone. Expand
A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies.
TLDR
The rapidly evolving field of gold nanoparticle thermal therapy is reviewed, highlighting recent literature and describing current challenges to clinical translation of the technology. Expand
Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727*
TLDR
The results provide the first evidence for a mechanism by which mitoStat3 contributes to tumorigenesis and suggest a novel role for mitostat3 in regulation of ROS concentrations through its action on the ETC. Expand
Dietary fibre and colorectal cancer: a model for environment--gene interactions.
TLDR
While several mechanisms might account for protection, the results of fermentation and especially butyrate production provide examples of how genomic instability might be controlled. Expand
A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon.
TLDR
It appears likely that ingested RS acts as a metabolic substrate, thus creating the right conditions for B. lactis to exert its proapoptotic action, and this combination facilitates the apoptotic response to DNA damage by a cancer initiator in the colon of rats. Expand
Novel Roles of GATA1 in Regulation of Angiogenic Factor AGGF1 and Endothelial Cell Function*
TLDR
It is demonstrated that GATA1 regulates expression of AGGF1 and reveal a novel role for GATA2 in endothelial cell biology and angiogenesis and one rare polymorphism in a sporadic KTS patient is identified. Expand
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
TLDR
It is identified that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of i ASPP dimerization, promotion of iAS PP monomer nuclear entry, and exposure of its p53 binding sites, leading to increased p53 inhibition. Expand
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