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Aquaporin-4 water channels play a central role in brain water regulation in neurological disorders. Aquaporin-4 is abundantly expressed at the astroglial endfeet facing the cerebral vasculature and the pial membrane, and both its expression level and subcellular localization significantly influence brain water transport. However, measurements of aquaporin-4(More)
SPECIATE is the U.S. Environmental Protection Agency's (EPA) repository of volatile organic compounds (VOCs) and particulate matter (PM) speciation profiles of air pollution sources. These source profiles can be used to (1) provide input to chemical mass balance (CMB) receptor models; (2) verify profiles derived from ambient measurements by multivariate(More)
NOTICE The U.S. Environmental Protection Agency through its Office of Research and Development funded and managed the research described here. It has been subjected to the Agency`s review and has been approved for publication as an EPA document. Mention of trade names, products, or services does not convey, and should not be interpreted as conveying,(More)
The goal of the present study is to integrate different datasets in cell biology to derive additional quantitative information about a gene or protein of interest within a single cell using computational simulations. We propose a novel prototype cell simulator as a quantitative tool to integrate datasets including dynamic information about transcript and(More)
Astrocytes are involved in many functions of the brain including water transport and moderation of neuronal synapses, and most functions require the astrocyte endfeet to be highly mobile. In the aging brain the functions in the brain start to deteriorate, decay or loss of metabolic functions may eventually cause diseases such as Parkinsons's and Alzheimer's(More)
Aquaporin-4 (AQP4) channels play an important role in brain water homeostasis. Water transport across plasma membranes has a critical role in brain water exchange of the normal and the diseased brain. AQP4 channels are implicated in the pathophysiology of hydrocephalus, a disease of water imbalance that leads to CSF accumulation in the ventricular system.(More)
Extracranial cerebrospinal fluid (CSF) shunt obstruction is one of the most important problems in hydrocephalus patient management. Despite ongoing research into better shunt design, robust and reliable detection of shunt malfunction remains elusive. The authors present a novel method of correlating degree of tissue ingrowth into ventricular CSF drainage(More)
The central nervous system (CNS) is the most difficult target for drug delivery therapies. Despite datasets available describing physiological, biochemical, cellular, and metabolic properties of the CNS, the development of infusion therapies still faces major delivery challenges. There is a need for the integration of data obtained from different(More)
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