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A series of new ureidoindolin-2-one derivatives were synthesized and evaluated as inhibitors of receptor tyrosine kinases. Investigation of structure-activity relationships at positions 5, 6, and 7… Continue Reading
A series of azulene-based derivatives were synthesized as potent inhibitors for receptor tyrosine kinases such as FMS-like tyrosine kinase 3 (FLT-3). Systematic side chain modification of prototype… Continue Reading
The precipitation of monosodium urate crystals within joints triggers an acute inflammatory reaction that is the root cause of gout. The inflammation induced by the injection of MSU crystals into the… Continue Reading
Cervical cancer is a common cancer amongst women, accounting for 9% of female cancer death. There are certain risk factors for the development of cervical cancer, in which human papilloma virus (HPV)… Continue Reading