• Publications
  • Influence
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.
TLDR
It is hypothesized that combined BER and NAD(+) biosynthesis inhibition will increase TMZ efficacy in glioblastoma cell lines greater than BER inhibition alone and significantly sensitizes glioma cells with elevated expression of MGMT and those deficient in MMR, two genotypes normally associated with TMZ resistance. Expand
Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice.
TLDR
The findings support the view that BER exerts antidepressant-like effect and may be related to the increase in NA and 5-HT levels in the hippocampus and frontal cortex. Expand
Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
TLDR
The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver. Expand
Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice.
TLDR
Results suggested that AGT possessed analgesic and anti-inflammatory effects, which might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver. Expand
α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii.
TLDR
It is demonstrated that PM may be a good source for lead compounds as alternatives for antidiabetic agents currently used and found the strong α-glucosidase and aldose reductase activities showed in the ethanol extracts of PM. Expand
Effects of trichostatin A on neuronal mu-opioid receptor gene expression
TLDR
Data suggest that TSA, an epigenetic regulator, affects neuronal MOR gene expression at both transcriptional and post-transcriptional levels. Expand
Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1.
TLDR
Oral administration of FR(EtOH) significantly reduces CCl(4)-induced hepatic fibrosis in rats, probably by exerting a protective effect against hepatocellular fibrosis by its free radical scavenging ability. Expand
Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism.
TLDR
The results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. Expand
Error-prone Replication Bypass of the Primary Aflatoxin B1 DNA Adduct, AFB1-N7-Gua*
TLDR
This is the first study demonstrating the mutagenicity of AFB1-N7-Gua in mammalian cells and the identification of candidate DNA polymerases involved in these processes, with contributions by both replicative and translesion synthesisDNA polymerases. Expand
Antioxidant, anti-inflammatory, and antiproliferative activities of Taxillus sutchuenensis.
TLDR
The experimental data indicated that T. sutchuenensis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds. Expand
...
1
2
3
4
5
...