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Primary Antibiotic Resistance of Helicobacter pylori in China
In China, the prevalence of H. pylori primary resistance to clarithromycin, metronidazole, and levofloxacin was high and increased over time, whereas the resistance rates to amoxicillin, tetracycline, and furazolidone were low and stable over time.
Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance
Novel regimens, e.g., vonoprazan-containing triple therapies, quintuple therapies, high-dose dual therapies, and standard triple therapies with probiotics, require further studies concerning their efficiency and safety for treating H. pylori.
Sex-specific association between the gut microbiome and high-fat diet-induced metabolic disorders in mice
It is identified that sex had a greater impact on the composition of gut microbiota than environmental factors (HFD and antibiotics) and the enrichment of beneficial microbes in female mice may be associated with the resistance of female mice to HFD-induced metabolic disorders, which was weakened by antibiotics.
A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period
Cholelithiasis was the main etiology in Jiangxi, China, and hyperlipidemia ranked second, and there were different etiological proportion according to age, sex, and severity, although there was no clear association between mortality and age.
Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases
The severity of APIP was associated with higher risk for neonate asphyxia, and maternal and fetal death, and lower level of serum calcium could be used as an indicator for the severity of the APIP.
Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway
The results indicate that PTEN phosphorylation at residues Ser380/Thr382/383 is a novel mechanism of PTEN inactivation in gastric carcinogenesis, and H. pylori triggers this modification, resulting in activation of the PI3K/Akt pathway and promotion of cell survival.
Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection.
Both 7- and 10-d quadruple furazolidone-based therapies achieve satisfactory H. pylori eradication rates, and the symptoms were relieved without special treatment in all of the patients.
Comparison of multifactor scoring systems and single serum markers for the early prediction of the severity of acute pancreatitis
Whether the current scoring systems and single serum markers used in pancreatitis remain applicable for the early prediction of infected pancreatic necrosis and the severity and mortality of acute pancreatitis in accordance with the revised Atlanta and determinant‐based classifications is clarified.
Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice
This study identifies the gut microbiota as an important mediator during AP and its dysbiosis is associated with AP severity, which suggests its role as potential therapeutic target.
Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway
- Nianshuang Li, Yan Feng, N. Lu
- Medicine, BiologyJournal of experimental & clinical cancer…
- 1 November 2018
BackgroundHelicobacter pylori (H. pylori) delivers oncoprotein CagA into gastric epithelial cells via the T4SS and drives activation of multiple oncogenic signalling pathways. YAP, a core effector of…