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OBJECTIVE To evaluate ustekinumab efficacy and safety in psoriatic arthritis (PsA) patients with peripheral arthritis and physician-reported spondylitis (termed the 'spondylitis subset'). METHODS Adults with active PsA (PSUMMIT-1/PSUMMIT-2, n=615/312) were randomised to ustekinumab 45 mg, 90 mg or placebo at week 0/week 4/q12 week. At week 16, patients(More)
IMPORTANCE The efficacy of treatment for psoriasis must be balanced against potential adverse events. OBJECTIVE To determine the effect of treatment on the risk of serious infections in patients with psoriasis. DESIGN, SETTING, AND PARTICIPANTS A multicenter, longitudinal, disease-based registry (Psoriasis Longitudinal Assessment and Registry [PSOLAR])(More)
BACKGROUND Patients with psoriasis are known to have an increased number of cardiovascular (CV) risk factors and be at increased risk for CV events. OBJECTIVES We sought to describe and characterize the underdiagnosis and undertreatment of CV risk factors in patients with moderate to severe psoriasis. METHODS Medical histories including diabetes,(More)
Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different(More)
BACKGROUND Comparing effectiveness of biologics in real-world settings will help inform treatment decisions. OBJECTIVES We sought to compare therapeutic responses among patients initiating infliximab, adalimumab, or etanercept versus ustekinumab during the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS Proportions of patients achieving(More)
The changes of fractal dimension ofPicea koraiensis seedlings under different light intensities in natural secondary forests was studied. The results showed that with the change of light environment, crown characters ofPicea koraiensis seedlings exhibited a greater plastic in lateral number, lateral increment, lateral dry weight, and specific leaf area. The(More)
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