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The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in(More)
Deadlock is an increasingly pressing concern as the multicore revolution forces parallel programming upon the average programmer. Existing approaches to deadlock impose onerous burdens on developers, entail high runtime performance overheads, or offer no help for unmodified legacy code. Gadara automates dynamic deadlock avoidance for conventional(More)
The maintenance of brain extracellular glutamate (Glu) at levels below its excitotoxic threshold is performed by Glu transporters present on glia and neurons as well as on brain capillary endothelial cells which remove brain Glu into blood. The feasibility of accelerating the naturally occurring brain-to-blood Glu efflux was studied using paradigms based on(More)
Molecular targeting of cancer stem cells (CSCs) has therapeutic potential for efficient treatment of cancer, although relatively few specific targets have been identified so far. Hypoxia-inducible factor (HIF) was recently shown to regulate the tumorigenic capacity of glioma stem cells under hypoxic conditions. Surprisingly, we found that, under normoxia,(More)
Human and animal studies suggest that acupuncture produces many beneficial effects through the central nervous system. However, the neural substrates of acupuncture actions are not completely clear to date. fMRI studies at Hegu (LI4) and Zusanli (ST36) indicated that the limbic system may play an important role for acupuncture effects. To test if this(More)
Activated phosphoinositide 3-kinase (PI3K) and its downstream target Akt are essential for the fibroblast transformation induced by many viral products. Tax, encoded by human T-cell leukemia virus type I (HTLV-I), has been demonstrated to induce the transformation of rat fibroblast Rat-1 cell through NF-κB activation. By stable transfection of Rat-1 cells(More)
When two people meet in a bar, a subtle interplay of social behaviours, including eye contact and unconscious mimicry of actions play an important role in how much the individuals like each other by the end of the evening. However, it is not known how these different social signals interact. Here, we adopt a rapid mimicry paradigm, to test if eye contact(More)
The inaccuracy of manually created digital road maps is a persistent problem, despite their high economic value. We present CrowdAtlas, which automates map update based on people's travels, either individually or crowdsourced. Its mobile navigation app detects significant portions of GPS traces that do not conform to the existing map, as determined by(More)
Constructive interference-based flooding (CIBF) is a latency-optimal flooding protocol, which can realize millisecond network flooding latency and submicrosecond time synchronization accuracy, require no network state information, and be adapted to topology changes. However, constructive interference (CI) has a precondition to function, i.e., the maximum(More)