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This study was aimed to elucidate the roles of inhibition of related JAK/STAT pathways in regulating cytotoxicity induced by cisplatin in non-small-cell lung cancer (NSCLC) cell. We treated five non-small-cell lung cancer cell lines with cisplatin alone or with cisplatin and Jak2 inhibitor (ruxolitinib) and assessed cell viability, expression of Jak2 and(More)
Neoaspergillic acid (NAA), a pyrazine hydroxamic acid, was produced by mixed cultures of two epiphytic fungi from a rotten fruit of mangrove Avicennia marina from the South China Sea. In the in vitro bioassays, NAA shows significant inhibitory activities against some Gram-positive and Gram-negative bacteria with MIC ranges of 0.49 – 15.62(More)
This paper studies the mechanism design that induces firms to provide public goods under two regulatory means: price cap regulation and optimal regulation, respectively. We first outline two models of monopoly regulation with unobservable marginal costs and effort, which can be regard as an optimal problem with dual restrictions. By solving this problem, we(More)
A new pathogenic Theileria species transmitted by Haemaphysalis qinghaiensis was identified in the Northwestern part of China and was shown to be highly pathogenic for small ruminants. The present article aimed at identifying merozoite antigens that might be suitable for developing diagnostic methods and designing a potential vaccine. Absence of other(More)
The gaseous chiral differentiation of alanine by permethylated β-cyclodextrin was studied using IRMPD spectroscopy and density functional theory calculations. The protonated non-covalent complexes of permethylated β-cyclodextrin and d- or l-alanine were mass-selected and investigated by IR laser pulses in the wavelength region of 2650-3800 cm-1. The(More)
Fluorescence decrease ratio was applied to determine of artemisinin (qinghaosu, QHS) based on the catalytic effect of hemoglobin (Hb) using tetraethyldiaminoxanthenyl chloride (Pryonine B, PB) as monitor in this work. Experimental result show that the catalytic characteristics of Hb for QHS, being expressed as Michaelis-Menten parameters,K m,V max, andK cat(More)
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