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Murine Models of Systemic Lupus Erythematosus

• Daniel Perry, Allison Sang, Yiming Yin, Ying-Yi Zheng, Laurence Morel
• Journal of biomedicine & biotechnology
• 1985

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus… (More)

Normalization of CD4+ T cell metabolism reverses lupus.

• Yiming Yin, Seung-Chul Choi, +6 authors Laurence Morel
• Science translational medicine
• 2015

Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for inflammatory effector functions, but… (More)

Wnt proteins regulate acetylcholine receptor clustering in muscle cells

• Bin Zhang, Chuan Liang, Ryan Bates, Yiming Yin, W. Xiong, Lin Mei
• Molecular Brain
• 2012

The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of… (More)

Animal models of molecular pathology systemic lupus erythematosus.

• Allison Sang, Yiming Yin, Ying-Yi Zheng, Laurence Morel
• Progress in molecular biology and translational…
• 2012

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems. A hallmark of SLE is the production of antinuclear antibodies against nuclear antigens such as… (More)

Dysregulated Cytokine Production by Dendritic Cells Modulates B Cell Responses in the NZM2410 Mouse Model of Lupus

• Allison Sang, Ying-Yi Zheng, +5 authors Laurence Morel
• PloS one
• 2014

The breakdown in tolerance of autoreactive B cells in the lupus-prone NZM2410-derived B6.Sle1.Sle2.Sle3 (TC) mice results in the secretion of autoantibodies. TC dendritic cells (DCs) enhance B cell… (More)

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4 T Cell Activation and Maps to Estrogen-Related Receptor g

• Laurence Morel, Daniel J. Perry, +4 authors András Perl
• 2012

Sle1c is a sublocus of the NZM2410-derived Sle1 major lupus susceptibility locus. We have shown previously that Sle1c contributes to lupus pathogenesis by conferring increased CD4 + T cell activation… (More)

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.

• Daniel J. Perry, Yiming Yin, +4 authors Laurence Morel
• Journal of immunology
• 2012

Sle1c is a sublocus of the NZM2410-derived Sle1 major lupus susceptibility locus. We have shown previously that Sle1c contributes to lupus pathogenesis by conferring increased CD4(+) T cell… (More)

Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.

• Carla M. Cuda, Shiwu Li, +11 authors Laurence Morel
• Journal of immunology
• 2012

Sle1a.1 is part of the Sle1 susceptibility locus, which has the strongest association with lupus nephritis in the NZM2410 mouse model. In this study, we show that Sle1a.1 results in the production of… (More)

Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.

• Yiming Yin, Seung-Chul Choi, +4 authors Laurence Morel
• Journal of immunology
• 2016

We have previously shown that CD4(+) T cells from B6.Sle1Sle2.Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-D-glucose, which inhibits glucose… (More)

[Clinical evaluations of lateral supraorbital microsurgical approach for sellar tumors].

• Yiming Yin, Gang Chen, Zhong Wang
• Zhonghua yi xue za zhi
• 2014

OBJECTIVE To assess the efficacy and safety of lateral supraorbital (LSO) approach for removing sellar tumors. METHODS Between June 2011 and December 2011, 23 patients with neoplastic lesions… (More)

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