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OBJECTIVE To investigate the association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of pulmonary cancer in Henan population. METHODS A case-control study of 209 lung cancer patients and 256 healthy control subjects was conducted in Henan population to investigate the role of CYP1A1-Msp1,(More)
Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. The biodistribution data showed that the(More)
BACKGROUND Heat shock protein 70 (Hsp70) has been shown to act as a chaperone and be associated with a variety of tumors. We investigated HSP70-1 G+190C, HSP70-2 A+1267G, and HSP70-hom T+2437C polymorphisms to assess whether genetic variation in HSP70 plays a role in the occurrence and development of lung cancer. METHODS A case-control study was conducted(More)
To develop a computer-aided diagnostic scheme of the CT in the diagnosis of lung cancer based on artificial neural networks (ANN) to assist radiologists in distinguishing malignant from benign pulmonary nodules. 117 CT images of pulmonary nodules (58 benign and 59 malignant) were analyzed. 21 CT radiological features of each case were carefully selected and(More)
A novel color image segmentation method based on finite Gaussian mixture model is proposed in this paper. First, we use EM algorithm to estimate the distribution of input image data and the number of mixture components is automatically determined by MML criterion. Then the segmentation is carried out by clustering each pixel into appropriate component(More)
In order to efficiently deliver chemotherapy drugs into hepatoma cells, a pH-sensitive and liver-targeted drug delivery system (glycyrrhetinic acid-modified alginate/doxorubicin-modified alginate complex nanoparticles), termed GA-ALG/DOX-ALG NPs, was prepared. First, GA-ALG and DOX-ALG were synthesized, and then GA-ALG/DOX-ALG NPs self-assembled by mixing(More)
Cytoplasmic dynein 1 is fundamentally important for transporting a variety of essential cargoes along microtubules within eukaryotic cells. However, in mammals, few mutants are available for studying the effects of defects in dynein-controlled processes in the context of the whole organism. Here, we deleted mouse Dlic1 gene encoding DLIC1, a subunit of the(More)
Optimization of network coverage is one of the hot issues of the research on wireless sensor network. The current discussion is generally based on the case of fixed node radius. Particle Swarm Optimization is a classical algorithm to control coverage rate. In this paper, a modified algorithm (D-PSO) is proposed to dynamically regulate node density. The(More)