Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
- Xiaojuan Han, Sifan Sun, G. Hu
- Biology, ChemistryAutophagy
- 9 April 2019
It is demonstrated that Ka promotes neuroinflammatory inhibition via the cooperation of ubiquitination and autophagy, suggesting that Ka is a promising therapeutic strategy for the treatment of NDDs.
POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
- Tao Yang, Yiming Sun, Zhiheng Xu
- Biology, ChemistryCell Reports
- 27 September 2012
MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells.
- Haihui Li, Pei Zhang, Xuegang Liu
- BiologyInternational Journal of Oncology
- 1 October 2015
It is demonstrated that miR-181a expression in lung adenocarcinoma is associated with EMT progression, potentially through targeting of PTEN, and Regulation of miR‑181a may provide a novel strategy for overcoming resistance to paclitaxel and cisplatin in lungAdenocARCinoma.
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression
- Xiao-dong Shu, Yiming Sun, G. Hu
- Biology, MedicineCell Death and Disease
- 1 August 2019
Insight is given into a novel approach to treat depression depending on astrocytes, and fluoxetine provides a promising molecular target for the development of antidepressant drugs besides regulating neurotransmitters.
Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis.
- Yu-Tyng Tai, Yiming Sun, Hao Liu
- BiologyExperimental and Therapeutic Medicine
- 1 October 2016
Results showed that the P. odoratum extract inhibited the proliferation and induced apoptosis of breast cancer MDA-MB-231 cells.
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.
- Dan Xu, Feng Zhang, Yaqing Wang, Yiming Sun, Zhiheng Xu
- BiologyCell Reports
- 16 January 2014
The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development*
- Yiming Sun, Teng Fei, Zhiheng Xu
- BiologyJournal of Biological Chemistry
- 6 October 2010
A novel mechanism that the BMP-SMAD signaling pathway controls neuronal migration and neurite outgrowth by suppressing the transcription of CRMP2 is revealed.
Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance
- Feng Zhang, Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu
- BiologyNature Communications
- 18 December 2014
It is shown that LSD1 is required for neuronal progenitor cell (NPC) maintenance during cortical development and hint at the potential application for the clinical drug, tranylcypromine, in the prevention and/or treatment of ATN1-associated degenerative disease, dentatorubral-pallidoluysian atrophy.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells
- Zhirui Zhang, Hong-Mei Li, Hao Liu
- Biology, MedicineJournal of experimental & clinical cancer…
- 22 September 2016
Findings supported that DHQ3 and 17-DR induce different forms of death in some cancer cell line via activation of different pathways, and provided evidence for its anti-tumorigentic action with low hepatotoxicity in vivo, making them promising anti-breast cancer agents.
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