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MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells.
TLDR
It is demonstrated that miR-181a expression in lung adenocarcinoma is associated with EMT progression, potentially through targeting of PTEN, and Regulation of miR‑181a may provide a novel strategy for overcoming resistance to paclitaxel and cisplatin in lungAdenocARCinoma.
POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
TLDR
A mechanism by which POSH regulates the localization of activated Rac1 and F-actin assembly to control PCDLP formation and subsequent somal translocation of migratory neurons is uncovered.
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
TLDR
It is demonstrated that Ka promotes neuroinflammatory inhibition via the cooperation of ubiquitination and autophagy, suggesting that Ka is a promising therapeutic strategy for the treatment of NDDs.
Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis.
TLDR
Results showed that the P. odoratum extract inhibited the proliferation and induced apoptosis of breast cancer MDA-MB-231 cells.
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.
TLDR
It is found that WDR62 knockdown leads to premature differentiation of neural progenitor cells (NPCs) and provides an insight into the molecular mechanisms underlying MCPH pathogenesis.
The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development*
TLDR
A novel mechanism that the BMP-SMAD signaling pathway controls neuronal migration and neurite outgrowth by suppressing the transcription of CRMP2 is revealed.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells
TLDR
Findings supported that DHQ3 and 17-DR induce different forms of death in some cancer cell line via activation of different pathways, and provided evidence for its anti-tumorigentic action with low hepatotoxicity in vivo, making them promising anti-breast cancer agents.
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer
TLDR
The results indicate that 3BP can suppress tumor growth and induce cell death by multiple mechanisms at the same time and concentration in different types of colon cancer cell by depleting cellular energy stores.
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression
TLDR
Insight is given into a novel approach to treat depression depending on astrocytes, and fluoxetine provides a promising molecular target for the development of antidepressant drugs besides regulating neurotransmitters.
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