Yimin Shen

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In the context of the renewed interest of peptides as therapeutics, it is important to have an on-line resource for 3D structure prediction of peptides with well-defined structures in aqueous solution. We present an updated version of PEP-FOLD allowing the treatment of both linear and disulphide bonded cyclic peptides with 9-36 amino acids. The server makes(More)
Despite intense investigation, human replication origins and termini remain elusive. Existing data have shown strong discrepancies. Here we sequenced highly purified Okazaki fragments from two cell types and, for the first time, quantitated replication fork directionality and delineated initiation and termination zones genome-wide. Replication initiates(More)
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Predicting accurate fragments from sequence has recently become a critical step for protein structure modeling, as protein fragment assembly techniques are presently among the most efficient approaches for de novo prediction. A key step in these approaches is, given the sequence of a protein to model, the identification of relevant fragments - candidate(More)
—Under the environment of Service-Oriented Architecture (SOA), service users have to decide how to choose the proper provider from the candidates to obtain optimal service level. The existing approaches based on the optimization theories usually ignore the decision conflicts among users, which result in periodic QoS fluctuation and poor system performance.(More)
brokers could find many service providers which offer same function with different quality of service (QoS). Under this condition, users may encounter difficulty to decide how to choose from the candidates to obtain optimal service quality. This paper tackles the Service Selection Problem (SSP) of time-sensitive services using the theory of games(More)
—The functional constraints of service matching and performance requirements (i.e., quality of service, QoS) of service selection are separated distinctly under the traditional service-oriented architecture (SOA). Hence the service matching and service selection may be performed in turn and independently. And the complexities of the implementation of SOA(More)
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