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Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain. Consequently, children are at a greater risk than adults of suffering from the neurotoxic effects of lead. To date, no safe lead-exposure threshold has been identified. The ability of lead to pass through the(More)
Recent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of bladder cancer (BC). The aim of our study was to identify serum miRNA expression signatures in patients with BC and establish new models for the diagnosis of BC and recurrence prediction. We performed genome-wide serum miRNA analysis by(More)
The Asian summer monsoon affects more than sixty percent of the world's population; understanding its controlling factors is becoming increasingly important due to the expanding human influence on the environment and climate and the need to adapt to global climate change. Various mechanisms have been suggested; however, an overarching paradigm delineating(More)
The influence on the summer flow over Asia of both the orographic and thermal forcing of the Tibetan Plateau is investigated using a sequence of idealised experiments with a global primitive equation model. The zonally averaged flow is prescribed and both realistic and idealised orography and heating are used. There is some similarity between the responses(More)
Differential metabolic responses to heat stress may be associated with variations in heat tolerance between cool-season (C₃) and warm-season (C₄) perennial grass species. The main objective of this study was to identify metabolites associated with differential heat tolerance between C₄ bermudagrass and C₃ Kentucky bluegrass by performing metabolite profile(More)
Semi-permanent high-pressure systems over the subtropical oceans, known as subtropical highs, influence atmospheric circulation, as well as global climate. For instance, subtropical highs largely determine the location of the world’s subtropical deserts, the zones of Mediterranean climate and the tracks of tropical cyclones. The intensity of two such(More)
Serum microRNAs (miRNAs) have become a highlighted research hotspot, especially for their great potential as a novel promising non-invasive biomarker in cancer diagnosis. The most frequently used approach for serum miRNAs detection is quantitative real time polymerase chain reaction (qPCR). In order to obtain reliable qPCR data of miRNAs expression, the use(More)
Clustering algorithms in general need the number of clusters as a priori, which is mostly hard for domain experts to estimate. In this paper, we use Niched Pareto k-means Genetic Algorithm (GA) for clustering. After running the multi-objective GA, we get the pareto-optimal front that gives the optimal number of clusters as a solution set. We analyze the(More)
Long non-coding RNAs (lncRNAs) are important regulators in pathological processes, yet their potential roles in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. Here, we found that a novel lncRNA, LOC389641, was upregulated in PDAC tissues and cell lines. The expression of LOC389641 was significantly correlated with staging, lymph node(More)