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In this work, we present a new optical routing framework, <i>O-Router</i> for future low-power on-chip optical interconnect integration utilizing silicon compatible nano-photonic devices. We formulate the optical layer routing problem as the minimization of total on-chip optical modulator cost (laser power consumption) with Integer Linear Programming(More)
This paper presents a class of hydration monitor that uses ultrathin, stretchable sheets with arrays of embedded impedance sensors for precise measurement and spatially multiplexed mapping. The devices contain miniaturized capacitive electrodes arranged in a matrix format, capable of integration with skin in a conformal, intimate manner due to the overall(More)
We report a complete genomic sequence of rare isolates (minor genotype) of the SARS-CoV from SARS patients in Guangdong, China, where the first few cases emerged. The most striking discovery from the isolate is an extra 29-nucleotide sequence located at the nucleotide positions between 27,863 and 27,864 (referred to the complete sequence of BJ01) within an(More)
The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth through transcriptional regulation of key genes regulating cell cycle arrest and apoptosis. In many types of cancer, in response to growth factor signaling, FoxO3a is phosphorylated by Akt, resulting in its exclusion from the nucleus. Here we show that FoxO3a remains(More)
Effective use of critical resources among threads remains a challenge to Simultaneous multithreading (SMT) due to transient behaviors of threads. As Issue Queue (IQ) is regarded as one of most critical shared resources in the pipeline, putting a limit on its occupation by each thread may easily improve the overall throughput, however, such a limit (cap)(More)
IEEE 802.16e standard is considered to be one of the most promising solutions for next generation broadband wireless networks. Still, handover latency in IEEE 802.16e networks is an important issue that affects real-time applications. In this paper, a cross-layer fast hierarchical handover mechanism (CLFH) for IEEE 802.16e networks is introduced. The(More)
microRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC by identifying its novel targets, as well as its underlying molecular mechanism. The expression of mitogen-activated protein kinase-kinase 3 (MAP2K3)(More)
The urokinase system is overexpressed in epithelial ovarian cancer cells and is expressed at low levels in normal cells. To develop a platform for intracellular and targeted delivery of therapeutics in ovarian cancer, we conjugated urokinase plasminogen activator (uPA) antibodies to liposomal nanobins. The arsenic trioxide-loaded nanobins had favorable(More)
In this paper, we study an often overlooked but very important and practical problem of building Buffering-aware Over-the-Block rectilinear Steiner minimum tree (BOB-RSMT). In most previous works, the routing resources over the IP blocks were simply treated as routing blockages, resulting in significant waste of routing resources on higher metal layers not(More)
— Simultaneous multi-threading (SMT) has been a very popular design in improving resource utilization by sharing key datapath components among multiple independent threads. When critical resources are shared by multiple threads, to effective use of these resources proves to be the most important factor in fully exploiting the system potential. Allowing any(More)