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Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify(More)
The vapor pressures and the aqueous solubilities of 411 compounds with a large structural diversity were investigated using a quantitative structure-property relationship (QSPR) approach. A five-descriptor equation with the squared correlation coefficient (R 2) of 0.949 for vapor pressure and a six-descriptor equation with R 2 of 0.879 for aqueous(More)
Delivery of therapeutic proteins across the blood-brain barrier (BBB) is severely limited by their size and biochemical properties. Here we showed that a 39-amino acid peptide derived from the rabies virus glycoprotein (RDP) was exploited as an efficient protein carrier for brain-targeting delivery. Three proteins with different molecular weight and pI,(More)
Aerobic methane-oxidizing bacteria (MOB) play a crucial role in mitigating the methane emission from lake ecosystems to the atmosphere. However, the distribution of methanotrophic community in shallow and eutrophic lake and its influential factors remain essentially unclear. The present study investigated sediment methanotrophic microorganisms at different(More)
The complex formation between sodium carboxymethylcellulose (NaCMC) and dodecyltrimethylammonium bromide (DTAB) at various sodium bromide concentrations (C(NaBr)) has been studied by microcalorimetry, turbidimetric titration, steady-state fluorescence measurements, and the fluorescence polarization technique. The addition of salt is found to influence the(More)
UNLABELLED Plant receptor-like kinases (RLKs) constitute a large family of receptors coordinating developmental programs with adaptation to environmental stresses including immune defenses. BRI1-ASSOCIATED KINASE 1 (BAK1), a member of the plant RLK family, forms receptor complexes with multiple RLK proteins including BRI1, FLS2, EFR and BIK1 to regulate(More)
Items in real-world recommender systems exhibit certain hierarchical structures. Similarly, user preferences also present hierarchical structures. Recent studies show that incorporating the explicit hierarchical structures of items or user preferences can improve the performance of recommender systems. However, explicit hierarchical structures are usually(More)
We participated in the Third International Chinese Word Segmentation Bake-off. Specifically, we evaluated our Chi-nese word segmenter NEUCipSeg in the close track, on all four corpora, namely Academis Sinica (AS), City University of Hong Kong (CITYU), Mi-crosoft Research (MSRA), and University of Pennsylvania/University of Col-orado (UPENN). Based on(More)
Cache invalidation is an important issue in mobile caching and has received much attention by researchers. However most existing studies on cache invalidation strategies are limited to cellular wireless networks in which the mobile terminals can communicate with the base stations directly. In this paper, we address the seldom studied issue of cache(More)
BACKGROUND A method for assessing dental maturity in different populations was first developed in 1973 by Demirjian and has been widely used and accepted since then. While the accuracy for evaluating dental age using Demirjian's method compared to children's chronological age has been extensively studied in recent years, the results currently available(More)