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The glycine-alanine repeat domain (GAr) of Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) prevents major histocompatibility complex (MHC) class I-restricted presentation of EBNA1 epitopes to cytotoxic T cells. This effect has previously been attributed to the ability of GAr to inhibit its own proteasomal degradation. Here we show, both in vitro and in(More)
In the classical model of chick wing digit-patterning, the polarizing region--a group of cells at the posterior margin of the early bud--produces a morphogen gradient, now known to be based on Sonic hedgehog (Shh), that progressively specifies anteroposterior positional identities in the posterior digit-forming region. Here we add an integral growth(More)
Sonic hedgehog (Shh) signalling by the polarizing region at the posterior margin of the chick wing bud is pivotal in patterning the digits but apart from a few key downstream genes, such as Hoxd13, which is expressed in the posterior region of the wing that gives rise to the digits, the genes that mediate the response to Shh signalling are not known. To(More)
OBJECTIVE To detect the functional networks of the red nucleus and substantia nigra during the resting state in normal subjects with functional magnetic resonance imaging (fMRI). METHODS Sixteen normal subjects were performed resting state fMRI scanning and susceptibility weighted imaging. The function connectivity networks base on seed regions of the red(More)
Primary cilia are important sites of signal transduction involved in a wide range of developmental functions. Here, we report an essential role of primary cilia in forebrain development. Standard genetic mapping and complementation analysis identified the ENU-generated mouse mutant cobblestone (cbs) as defective in the gene Ift88 (Intraflagellar transport,(More)
Dublin, Bath and London. This database will be based on EMAGE and cross-referenced to the mouse through orthologous gene pairsout this project, the data and framework will be used to identify groups of genes that are co-expressed in important signalling regions. Conservation of these genes will be examined in the chick and mouse. This database will be made(More)
When doing business process modeling and analyzing, the most frequently used methods are based on workflow technology. However, traditional workflow management systems are heavyweight and monolithic, and could not be easily reused. This paper proposes an approach of business process depicting and analyzing (BPDA). This approach decomposes the business(More)
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