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Polymer-nanoparticle-encapsulated doxorubicin (DOX) and paclitaxel (TAX) have the potential for novel therapeutic use against cancer in the clinic. However, the systemic biological effect of the nanoparticle material, namely, methoxypoly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA), and its encapsulated drugs have not been fully studied. We have(More)
Cetyltrimethylammonim bromide coated gold nanorods (Au NRs) has a potential to become anti-cancer nano-drugs. Previously, the comparative responses of human alveolar adenocarcinoma epithelial cells (A549) and normal bronchial epithelial cells (16HBE) exposed to Au NRs have been characterized. It has been shown that Au NRs are translocated from the lysosome(More)
Here, we show that miR-515-5p inhibits cancer cell migration and metastasis. RNA-seq analyses of both oestrogen receptor receptor-positive and receptor-negative breast cancer cells overexpressing miR-515-5p reveal down-regulation of NRAS, FZD4, CDC42BPA, PIK3C2B and MARK4 mRNAs. We demonstrate that miR-515-5p inhibits MARK4 directly 3' UTR interaction and(More)
In computer vision, many applications could greatly benefit from multi-spectral image data. Our aim is to illustrate the effectiveness of multi-spectral analysis obtained from a simple and cost-effective system. While the proposed approach is broadly applicable, in this paper we focus on the specific case of skin detection. To obtain the multi-spectral(More)
† State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of 6 Contemporary Anthropology, Collaborative Innovation Centre for Genetics and Development, 7 Shanghai International Centre for Molecular Phenomics, Metabonomics and Systems Biology 8 Laboratory, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai(More)
This paper describes an image analysis technique that objectively study the skin pigments disorders which can be useful in assessment of treatment. The word Pigmentation means coloring. Skin pigmentation disorders affect the color of the skin. Therapeutic response of treatment results in repigmentation of the skin. However the repigmentation process is very
Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lactide-co-glycolide) modified with ε-polylysine, and encapsulated with(More)
The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen,(More)
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation. To overcome this problem, we analysed the metabonomic differences between two independent pairs of(More)
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