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Genetically encoded voltage sensors expand the optogenetics toolkit into the important realm of electrical recording, enabling researchers to study the dynamic activity of complex neural circuits in real time. However, these probes have thus far performed poorly when tested in intact neural circuits. Hybrid voltage sensors (hVOS) enable the imaging of(More)
The complex and malleable conduction properties of axons determine how action potentials propagate through extensive axonal arbors to reach synaptic terminals. The excitability of axonal membranes plays a major role in neural circuit function, but because most axons are too thin for conventional electrical recording, their properties remain largely(More)
Ghitani N, Bayguinov PO, Ma Y, Jackson MB. Single-trial imaging of spikes and synaptic potentials in single neurons in brain slices with genetically encoded hybrid voltage sensor. J Neurophysiol 113: 1249 –1259, 2015. First published November 19, 2014; doi:10.1152/jn.00691.2014.—Genetically encoded voltage sensors expand the optogenetics toolkit into the(More)
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