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Antibody-therapeutic agent conjugates to be delivered directly into the cytosol of tumour cells is required for many target-based therapeutic strategies. For this work, a large non-immune phage-display library was used to select internalizing scFv (single chain variable fragment) directed against EGFR (epidermal growth factor receptor), a tyrosine kinase(More)
Journal writing is an important and common reflective practice in education. Students' reflection journals also offer a rich source of data for formative assessment. However, the analysis of the textual reflections in class of large size presents challenges. Automatic analysis of students' reflective writing holds great promise for providing adaptive real(More)
IL-33, a new member of the IL-1 cytokine family, is associated with many infectious diseases. IL-33 not only is crucial for induction of Th2 polarized responses, but also is involved in induction of inflammation as a proinflammatory cytokine. Whether IL-33 leads to beneficial or worsening outcomes depends on the immune mechanism underlying the pathogensis(More)
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