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[Experimental study on tissue engineered cartilage complex three-dimensional nano-scaffold with collagen type II and hyaluronic acid in vitro].
TLDR
The collage type II and HA complex three-dimensional nano-scaffold has good physicochemical properties and excellent biocompatibility, so it can be used as a tissue engineered cartilage.
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Repair of articular cartilage defects in rabbits through tissue-engineered cartilage constructed with chitosan hydrogel and chondrocytes
TLDR
The novel tissue-engineered cartilage constructed in this research can completely repair the structure of damaged articular cartilage.
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Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells
TLDR
The data suggest that Ad-GDF-5 gene therapy is a potential treatment for IDD, which restores the functions of degenerative intervertebral disc through enhancing the ECM production of human NP cells.
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Effects of inhibiting PDK-1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro
TLDR
Investigation of the role of PDK-1 in the process of mouse osteoblast differentiation in vitro indicated that BX-912 and disruption of the PDk-1 gene in vitro significantly inhibited the differentiation and maturation of osteoblasts.
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Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation
TLDR
In osteoblasts derived from PDK‐1 cKO mice, the alkaline phosphatase secretion and ability of calcium mineralization were significantly decreased, and the expressions of osteoblast‐related proteins, runt‐related transcription factor 2, OCN, and ALP were also clearly decreased.
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Deficiency of PDK1 in osteoclasts delays fracture healing and repair
TLDR
It is revealed, using the tibial fracture model, that the specific deletion of the PDK1 gene in osteoclasts impeded the fracture healing process by delaying the resorption of the cartilaginous callus and subsequent remodeling of immature woven bone to structurally and mechanically ensure lamellar bone is stronger.
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Adapalene Inhibits Prostate Cancer Cell Proliferation In Vitro and In Vivo by Inducing DNA Damage, S-phase Cell Cycle Arrest, and Apoptosis
TLDR
The results suggest that ADA may be a potential treatment against prostate cancer, and it is observed that ADA could effectively inhibited tumor growth and bone destruction in mice.
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The efficacy of combination of chemotherapy and cytokine-induced killer cells therapy for soft tissue cancer : a meta-analysis
TLDR
The combination of chemotherapy and CIK cells treatment improves the OS for patients with soft tissue cancer, especially for gastric cancer patients, and should be recommended for Patients with multiple types of soft tissue tumors.
Conditional Knockout of PDK1 in Osteoclasts Suppressed Osteoclastogenesis and Ameliorated Prostate Cancer-Induced Osteolysis
TLDR
PDK1 performs an instrumental function in osteoclastogenesis and prostate cancer-induced osteolysis by modulating the PDK1/AKT/NF-κB signaling pathway.
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Treatments for intervertebral discs degeneration by stem cells transplantation : a therapeutic potential comparison between bone marrow stem cells and adipose-derived stem cells
TLDR
The BMSCs transplantation was more effective in the disc degeneration treatment than ADSCs, which appears to be an ideal substitute for NPCs.
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