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WebView is an essential component in both Android and iOS platforms, enabling smartphone and tablet apps to embed a simple but powerful browser inside them. To achieve a better interaction between apps and their embedded "browsers", WebView provides a number of APIs, allowing code in apps to invoke and be invoked by the JavaScript code within the web pages,(More)
Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity to inflammation are not fully understood. Follistatin-like 1 (FSTL1) is a novel proinflammatory cytokine that is expressed in adipose tissue and secreted by(More)
INTRODUCTION SNX-2112 is a promising anticancer agent but has poor solubility in both water and oil. In the study reported here, we aimed to develop a nanocrystal formulation for SNX-2112 and to determine the pharmacokinetic behaviors of the prepared nanocrystals. METHODS Nanocrystals of SNX-2112 were prepared using the wet-media milling technique and(More)
Cranberry flavonoids (flavonols and flavan-3-ols), in addition to their antioxidant properties, have been shown to possess potential in vitro activity against several cancers. However, the difficulty of isolating cranberry compounds has largely limited anticancer research to crude fractions without well-defined compound composition. In this study,(More)
Carbon offsets are becoming a necessary tool in carbon emission reduction. The offsets obtained through sequestration in coastal wetland vegetation and sediment is referred to as blue carbon. Our client, the Duke Carbon Offset Initiative (DCOI), is currently researching blue carbon to help meet Duke University's goal of carbon neutrality by 2024. Through(More)
Lewis (y) antigen is a difucosylated oligosaccharide present on the plasma membrane, and its overexpression is frequently found in human cancers and has been shown to be associated with poor prognosis. Our previous studies have shown that Lewis (y) antigen plays a positive role in the process of invasion and metastasis of ovarian cancer cells. However, the(More)
BACKGROUND Astrocytoma is a common aggressive intracranial tumor and presents a formidable challenge in the clinic. Association of altered DNA methylation patterns of the promoter CpG islands with the expression profile of cancer-related genes, has been found in many human tumors. Therefore, DNA methylation status as such may serve as an epigenetic(More)
Protein methylation is one type of reversible post-translational modifications (PTMs), which plays vital roles in many cellular processes such as transcription activity, DNA repair. Experimental identification of methylation sites on proteins without prior knowledge is costly and time-consuming. In silico prediction of methylation sites might not only(More)
In Android applications, third-party components may bring potential security problems, because they have the same privilege as the applications but cannot be fully trusted. It is desirable if their privileges can be restricted. To minimize the privilege of the third-party components, we develop Compac to achieve a fine-grained access control at(More)