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Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), we identified 45 candidate lncRNAs associated with risk to prostate cancer. We further evaluated the mechanism(More)
Aleksandar Donev, ∗ Andy Nonaka, Yifei Sun, 3 Thomas G. Fai, Alejandro L. Garcia, and John B. Bell Courant Institute of Mathematical Sciences, New York University, New York, NY 10012 Center for Computational Science and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720 Leon H. Charney Division of Cardiology, Department of Medicine, New(More)
Polychlorinated biphenyls (PCBs) and chlorobenzenes (CBzs) are two classes of dioxin precursors formed in municipal solid waste incinerators (MSWIs) producing negative health effects similar to those of dioxins. Reducing the analytical time required for determining the concentrations of these compounds in MSWIs is important for quickly evaluating their(More)
We present data from a between-student study on student response to questions on Newton’s third law given in two introductory calculus-based physics classes (Mechanics and Electromagnetism) at a large northeastern university. Construction of a response curve reveals subtle dynamics in student learning not capturable by pretesting and post-testing. We find a(More)
This study systematically examines foreign R&D in China’s manufacturing industries, using the most recent census data published by China’s State Council. It reveals that foreign firms are committing less R&D resource than China’s domestic enterprises. Foreign R&D activities are far more active in high-tech industries than in labour-intensive industries.(More)
YIFEI SUN*†, YU ZHOU‡, GEORGE C. S. LIN§ and Y. H. DENNIS WEI} *Institute of China Innovation (ICI), East China Normal University, Shanghai 200062, China †Department of Geography, California State University –Northridge, Northridge, CA 91330, USA. Email: Yifei.sun@csun.edu ‡Department of Earth Science and Geography, Vassar College, Poughkeepsie, NY 12604,(More)
Heat shock protein 90 (Hsp90) is a fascinating target for cancer therapy due to its significant role in the crossroad of multiple signaling pathways associated with cell proliferation and regulation. Hsp90 inhibitors have the potential to be developed into anti-cancer drugs. Here, we identified nicotinic-mycoepoxydiene (NMD), a structurally novel compound(More)
Cancer-initiating cells (CIC) undergo asymmetric growth patterns that increase phenotypic diversity and drive selection for chemotherapeutic resistance and tumor relapse. WNT signaling is a hallmark of colon CIC, often caused by APC mutations, which enable activation of β-catenin and MYC Accumulating evidence indicates that long noncoding RNAs (lncRNA)(More)
UNLABELLED Although endocrine therapy is an effective method to treat estrogen receptor (ER)-positive breast cancer, approximately 30%-40% of all hormone receptor-positive tumors display de novo resistance. The aim of our current study was to analyze whether (18)F-labeled fluoromisonidazole (1-(2-nitro-1-imidazolyl)-2-hydroxy-3-fluoropropane [(18)F-FMISO])(More)