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Vessel maturation effects on tumour growth: validation of a computer model in implanted human ovarian carcinoma spheroids.
We analysed measurements of tumour growth, neovascular maturation and function in human epithelial ovarian carcinoma xenografts, studied noninvasively by magnetic resonance imaging. Results suggestExpand
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Application of the Virtual Cancer Patient Engine (VCPE) for improving oncological treatment desig.
692 Background Physicians are limited in their capacity to individually patient-tailor the safest and most efficient treatments in terms of drug and schedule choices, partly due to individualExpand
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Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency
The Nucleosome Remodeling and Deacytelase (NuRD) complex is a corepressive complex involved in many pathological and physiological processes in the cell. Previous studies have identified one of itsExpand
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Role of Angiopoietin-1 (ANG1) in antiangiogenic cancer therapy - computer analysis of a physiologically based model of tumor angiogenesis.
3095 Background: Inhibition of tumor angiogenesis is one of the intensively investigated new approaches for cancer treatment. ANG1 is a protein that promotes interaction of endothelial cells withExpand
Phenotypic screen identifies JAK2 as a major regulator of FAT10 expression.
FAT10 is a ubiquitin-like protein suggested to target proteins for proteasomal degradation. It is highly upregulated upon pro-inflammatory cytokines namely TNFα, IFNγ and IL6, and was found to beExpand