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Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) have been already used to perform noninvasive prenatal paternity testing from maternal plasma DNA. The frequently used technologies were PCR followed by capillary electrophoresis and SNP typing array, respectively. Here, we developed a noninvasive prenatal paternity testing (NIPAT) based(More)
A simple sensitive and robust method for simultaneous determination of citalopram and desmethylcitalopram was developed using liquid chromatography tandem mass spectrometry (LC-MS/MS). A 200 microL aliquot of plasma sample was employed and deproteinized with methanol and desipramine was used as the internal standard. After vortex mixing and centrifugation,(More)
CD41 (αIIb integrin), a specific marker for megakaryocytes and platelets, was recently shown to mark the initiation of definitive hematopoiesis in mouse embryos. However, whether embryonic CD41(+) populations have a nonhematopoietic potential remains elusive. Here, we report that the CD41(+) cells from the mouse E11.0 aorta-gonad-mesonephros (AGM) region(More)
BACKGROUND Citalopram is a selective serotonin reuptake inhibitor (SSRI) mainly prescribed to treat major depression. OBJECTIVE The aim of this study was to compare the pharmacokinetic characteristics of a new and a branded citalopram 20 mg formulation to support the marketing authorization of the test formulation in China. METHODS A single-dose,(More)
For splitting target tracking, the target may split into several such that estimating the states of all targets respon-sively and accurately becomes crucial. The standard formulation of the CBMeMBer filter assumes that the target birth intensity is known as a priori. In consideration of the fact that the target splitting event should be random and could(More)
BACKGROUND With the speedy development of sequencing technologies, noninvasive prenatal testing (NIPT) has been widely applied in clinical practice for testing for fetal aneuploidy. The cell-free fetal DNA (cffDNA) concentration in maternal plasma is the most critical parameter for this technology because it affects the accuracy of NIPT-based sequencing for(More)
The new concept of keeping primary tumor under control in situ to suppress distant foci sheds light on the novel treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. In this study, a novel thermal modality was built to introduce hyperthermia effect on tumor to suppress its growth and progression using(More)
In a Y-shaped passive linear array sonar (PLAS) system, three sensor legs are configured and report bearings-only measurements, which are complicated due to bearing-ambiguity. As many ghost targets exist, multi-target tracking using a PLAS system is a challenging problem, especially when target miss-detection and clutter are also considered. In this paper,(More)
The conventional multi-target tracking (MTT) algorithms usually suffer from computational intractability problem. The appearance of Iterative Joint Integrated Probabilistic Data Association (iJIPDA) filter solves this problem by providing a tradeoff between the tracking performance and computational cost for computational resource management of sensor(More)