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Glutathione S-transferase P1(GSTP1) plays an important role in the detoxification and xenobiotics metabolism. Here, we show that GSTP1 is also involved in LPS (lipopolysaccharide)-induced inflammatory response. GSTP1 expression, determined at the transcription and translation levels, were upregulated by the LPS stimulation in RAW264.7 macrophage-like cells.(More)
In resource-constrained systems, the interference generated by the concurrent execution of multiple controller tasks leads to extra delay and jitter, which degrade control performance and may even jeopardize the stability of the controlled system. This work presents a general methodology that integrates control issues and real-time schedulability analysis(More)
We consider a sequential learning problem with Gaussian payoffs and side observations: after selecting an action i, the learner receives information about the payoff of every action j in the form of Gaussian observations whose mean is the same as the mean payoff, but the variance depends on the pair (i, j) (and may be infinite). The setup allows a more(More)
Heat shock protein 27 (HSP27) is an ubiquitiously expressed protein, which has been mediated in various biological functions. Here, we present a novel mechanism utilized by HSP27 in regulating IL-1beta induced NF-small ka, CyrillicB activation. Both over-expression and RNAi experiments indicate that HSP27 physically interacts with tumor necrosis factor(More)
Glutathione S-transferase P1 (GSTP1) plays an important role in detoxification and the metabolism of xenobiotics. Here we show that GSTP1 also regulates the MEKK1-MKK7 signaling pathway. Over-expression of GSTP1 in HEK293 cells inhibited both DMEKK1- and etoposide-induced apoptosis, and inhibited pro-caspase-3 activation and PARP cleavage. MEKK1-induced(More)
This paper describes the design, modeling, fabrication and characterization MEMS Coulter counter that can detect and monitor the dynamic cell impedance changes in situ as a function of time after mixing isolated cell populations with different extracellular media within 0.3 s from the start of mixing. The novelty of this design is the use of(More)
The extracellular portion (amino acids 95–281 or 114–281) of the human tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) was genetically linked to the C terminus of the fluoresce-enhanced green fluorescent protein variant (EGFP) to generate two versions of EGFP–sTRAIL fusion proteins, designated EGFP–sTR95 and EGFP–sTR114, respectively. The(More)
The vascular grafts prepared by electrospinning often have relatively small pores, which limit cell infiltration into the grafts and hinder the regeneration and remodeling of the grafts into neoarteries. To overcome this problem, macroporous electrospun polycaprolactone (PCL) scaffolds with thicker fibers (5-6 μm) and larger pores (∼30 μm) were fabricated(More)
Inducible heat shock protein 70 (Hsp70) is one of the most important HSPs for maintenance of cell integrity during normal cellular growth as well as pathophysiological conditions. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial signaling transducer that regulates a diverse array of physiological and pathological processes and is(More)