Yifan Lu

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In Alzheimer disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and other tauopathies, tau accumulates and forms paired helical filaments (PHFs) in the brain. Tau isolated from PHFs is phosphorylated at a number of sites, migrates as approximately 60-, 64-, and 68-kDa bands on SDS-gel, and does not promote microtubule(More)
Plaques containing beta-amyloid (Abeta) peptides are one of the pathological features of Alzheimer's disease, and the reduction of Abeta is considered a primary therapeutic target. Amyloid clearance by anti-Abeta antibodies has been reported after immunization, and recent data have shown that the antibodies may act as a peripheral sink for Abeta, thus(More)
Research into optical markerless human motion capture has attracted significant attention. However, the complexity of the human anatomy, ambiguities introduced by lacking full-perspective view data and noises involved in data processing make human motion capture a non-convex, multi-modal optimisation problem in high dimensional space. The proposed method(More)
In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics. In Alzheimer disease (AD), tau is abnormally hyperphosphorylated, leading to neurofibrillary tangle formation and microtubule disruption, suggesting a loss of regulatory(More)
Acknowledgements Thanks to Supervisors Rhys Hawkins and Dr. Henry Gadner for guidance of the project. Thanks to Ian Farrington for providing the useful information and access to the archaeological laboratory. Abstract The problem of reassembling archaeological artefacts from a collection of fragments that may include other fragments from several artefact(More)
The powerful theory of compressive sensing enables an efficient way to recover sparse or compressible signals from non-adaptive, sub-Nyquist-rate linear measurements. We propose a compressive an-neal particle filter to exploit sparsity existing in image-based human motion tracking. Interestingly, it has been shown that random projections can well(More)
The major issue in markerless motion capture is finding the global optimum from the multimodal setting where distinctive gestures may have similar likelihood values. Instead of only focusing on effective searching as many existing works, our approach resolves gesture ambiguity by designing a better-behaved observation likelihood. We extend Annealed Particle(More)