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The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression
TLDR
SPRY4-IT1 is a novel prognostic biomarker and a potential therapeutic candidate for breast cancer and the first demonstration that ZNF703 plays an oncogenic role in ER (−) breast carcinoma cells is provided.
High expression of long non-coding RNA ZEB1-AS1 promotes colorectal cancer cell proliferation partially by suppressing p15 expression
TLDR
It turns out that ZEB1-AS1 is upregulated in colorectal cancer tissues and its expression is significantly associated with overall survival rate and recurrence-free survival.
LINC00152: A pivotal oncogenic long non‐coding RNA in human cancers
TLDR
Increasing evidence has showed that LINC00152 may act as a diagnostic and prognostic biomarker for the above‐mentioned cancers, and the expression and role of LINC 00152 in various kinds of cancers is summarized.
DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2
TLDR
The results suggest that tumor expression of pseudogene derived lncRNA DUXAP8 plays an important role in pancreatic cancer progression and may serve as a candidate biomarker and represent a novel therapeutic target of Pancreatic cancer.
The long non‐coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell
TLDR
This study suggests that PVT1 could play an essential role in preeclampsia progression and probably acts as a latent therapeutic marker; thus, it might be a useful prognostic marker when evaluating new therapies for patients with preeClampsia.
Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma
TLDR
High expression of XPOs was associated with a poor prognosis in HCC patients, and XPO1, CSE1L, XPOT, XPO4/5/6 was related to poor overall survival (OS), and XP oocyte meiosis routes were correlated with poor disease-free survival (DFS).
Long non‐coding RNA FOXP4‐AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer
TLDR
It is reported that lncRNA FOXP4‐AS1 acts as a functional oncogene in CRC pathogenesis and the effects of FOXP2‐AS2 on tumour progression are investigated, both in vitro and in vivo.
Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades
TLDR
The results suggest that Loc554202 may play an important role in the progression of CRC and could be a candidate prognostic biomarker or a target for new cancer therapies.
The lncRNA-HOXA-AS2/EZH2/LSD1 oncogene complex promotes cell proliferation in pancreatic cancer.
TLDR
It is demonstrated that lncRNA-HOXA-AS2/EZH2/LSD1 complex may function as an oncogene in PC cell proliferation, and also provides a potential therapy target for PC.
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