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The hypothesis that a high salt (HS) intake increases oxidative stress was investigated and was related to renal cortical expression of NAD(P)H oxidase and superoxide dismutase (SOD). 8-Isoprostane PGF(2alpha) and malonyldialdehyde were measured in groups (n = 6 to 8) of conscious rats during low-salt, normal-salt, or HS diets. NADPH- and NADH-stimulated(More)
CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Significantly, the CISD2 gene is located on human chromosome 4q, where a genetic component for longevity maps. Here we show for the first time that CISD2 is involved in mammalian life-span control. Cisd2 deficiency in mice causes mitochondrial breakdown and(More)
A new method of surface-quality assessment is presented. The model of highlight lines is introduced, and its properties and applications in surface-quality evaluation are demonstrated. The differential equation of the highlight-line model is derived, and the difficulty involved in seeking its analytical solutions is discussed. Alternatively, the creation of(More)
OBJECTIVE The objective of the present study was to investigate the feasibility and reliability of sintering alumina and zirconia-based all-ceramic materials through a recently introduced microwave heating technique. The variation of crystal phases, the growth of grain sizes and microstructural features of these materials were evaluated after sintering. (More)
OBJECTIVE We compared the use of two active cooling devices with passive cooling in a moderate-temperature (≈ 22 °C) environment on heart rate (HR) and core temperature (T(c)) recovery when applied to firefighters following 20 minutes of fire suppression. METHODS Firefighters (23 men, two women) performed 20 minutes of fire suppression at a live-fire(More)
CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is an evolutionarily conserved novel gene. Recently, we have demonstrated that CISD2 is involved in mammalian lifespan control; this work also establishes WFS2 as a mitochondria-mediated disorder and effectively links CISD2 gene function, mitochondrial integrity, and aging in mammals. In wild-type(More)