Total fractionation and characterization of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer.
The Inhibitory Effects of a Rhamnogalacturonan Ι (RG-I) Domain from Ginseng Pectin on Galectin-3 and Its Structure-Activity Relationship*
The novel discovery that the side chains and backbone play distinct roles in regulating RG-I-4 activity is valuable for producing highly active pectin-based galctin-3 inhibitors.
Highly selective biotransformation of ginsenoside Rb1 to Rd by the phytopathogenic fungus Cladosporium fulvum (syn. Fulvia fulva)
Cladosporium fulvum, a tomato pathogen, was found to transform major ginsenoside Rb1 to Rd as the sole product, which has potential to be applied on the preparation for Rd in pharmaceutical industry.
A novel ginsenoside Rb1-hydrolyzing β-D-glucosidase from Cladosporium fulvum
Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer.
Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracil.
A neutral polysaccharide fraction prepared from Panax ginseng C.A. Meyer was tested and it was suggested that WGPN might be a potential adjuvant for chemotherapeutic drugs.
Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells
The temperature-modified HG-rich pectin had dramatically increased antiproliferative effect and induced apoptosis accompanied by the activation of caspase-3, and starch-like glucan and arabinogalactan of ginseng exhibited no antiprolliferative effects.
Modified Heparin Inhibits P-selectin-mediated Cell Adhesion of Human Colon Carcinoma Cells to Immobilized Platelets under Dynamic Flow Conditions*
The findings suggested that the 6-O-sulfate group of glucosamine units in heparin is critical for the inhibition of P-selectin-mediated tumor cell adhesion.
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice
An anti-sense lncRNA (APOA4-AS) is uncovered, which is co-expressed with APOA4, and concordantly and specifically regulates APoa4 expression both in vitro and in vivo with the involvement of HuR.
In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants
It is proposed that the activity of the glycoalkaloids against Plasmodium yoelii is dependent upon non-specific carbohydrate interactions and the 6-OH of chaconine is important for antimalarial activity.