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c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart
Although transplantation of c-kit+ cardiac stem cells (CSCs) has been shown to alleviate left ventricular (LV) dysfunction induced by myocardial infarction (MI), the number of exogenous CSCsExpand
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The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): A New Paradigm for Rigorous, Accurate, and Reproducible Evaluation of Putative Infarct-Sparing
Rationale: Despite 4 decades of intense effort and substantial financial investment, the cardioprotection field has failed to deliver a single drug that effectively reduces myocardial infarct size inExpand
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Preconditioning Human Cardiac Stem Cells with an HO‐1 Inducer Exerts Beneficial Effects After Cell Transplantation in the Infarcted Murine Heart
The regenerative potential of c‐kit+ cardiac stem cells (CSCs) is severely limited by the poor survival of cells after transplantation in the infarcted heart. We have previously demonstrated thatExpand
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Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence.
BACKGROUND The authors previously reported that the c-kit-positive (c-kitPOS) cells isolated from slowly adhering (SA) but not from rapidly adhering (RA) fractions of cardiac mesenchymal cells (CMCs)Expand
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Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction
We have recently demonstrated that repeated administrations of c-kitPOS cardiac progenitor cells (CPCs) have cumulative beneficial effects in rats with old myocardial infarction (MI), resulting inExpand
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Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair
Although cell therapy improves cardiac function after myocardial infarction, highly variable results and limited understanding of the underlying mechanisms preclude its clinical translation. BecauseExpand
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Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury
The role of cyclooxygenase-2 (COX-2) in cardiovascular biology remains controversial. Although COX-2 has been reported to mediate the protective actions of late preconditioning, other studies showExpand
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Astragalus Granule Prevents Ca2+ Current Remodeling in Heart Failure by the Downregulation of CaMKII
Background Astragalus was broadly used for treating heart failure (HF) and arrhythmias in East Asia for thousands of years. Astragalus granule (AG), extracted from Astragalus, shows beneficial effectExpand
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A Juvenile Murine Heart Failure Model of Pressure Overload
Persistent pressure overload can cause cardiac hypertrophy and progressive heart failure (HF). The authors developed a pressure-overload HF model of juvenile mice to study the cardiac response toExpand
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Abstract 16843: Early Preconditioning Reduces No-reflow Independently of Infarct Size in Prolonged Ischemia and Benefits Cardiac Remodeling in Mouse
Coronary microvascular no-reflow commonly coexists with infarcted cardiomyocyte in reperfused myocardium. Recent studies point to microcirculation as a target, different from infarction size, in ca...
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