Yibing Chen

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T he excitement of scientifi c research and discovery cannot be fully conveyed by didactic lectures alone. Several recent initiatives and proposals, therefore, have supported a more participatory, discovery-based instruction for undergraduate science education [1,2]. In functional genomics, we have found an ideal platform to simultaneously benefi t students(More)
With the rapid development of on-line information services, information technologies for on-line information processing have been receiving much attention recently. Clustering plays important roles in various on-line applications such as extraction of useful information from news feeding services and selection of relevant documents from the incoming(More)
BACKGROUND High frequency of loss of heterozygosity (LOH) was found at D7S486 in primary gastric cancer (GC). And we found a high frequency of LOH region on 7q31 in primary GC from China, and identified D7S486 to be the most frequent LOH locus. This study was aimed to determine what genes were affected by the LOH and served as tumor suppressor genes (TSGs)(More)
This paper proposes a two-phase feature selection method specific for bioinformatics domain from classification perspective in data mining. In the first phase, Bhattacharyya distance measurement is used for filtering the majority of irrelevant genes. Upon the basis, we apply floating sequential search method (FSSM) to further select informative gene set(More)
Non-small cell lung cancer (NSCLC) is characterized by poor prognosis and only a few molecular markers may be potentially used to predict clinical outcomes. Previous studies have demonstrated that monocarboxylate transporters (MCTs) play important roles in the development and progression of many cancers. The purpose of this study was to assess the effects(More)
Compelling epidemiological evidences indicate a significant association between leukocyte mitochondrial DNA (mtDNA) content and incidence risk of several malignancies, including hepatocellular carcinoma (HCC). However, whether leukocyte mtDNA content affect prognosis of HCC patients and underlying mechanism has never been explored. In our study, leukocyte(More)
INTRODUCTION Previous studies have demonstrated that the expression of cytochrome c oxidase (COX) subunits encoded by mitochondrial DNA is elevated in colorectal cancer (CRC). However, the expression of nuclear DNA-encoded COX IV and its clinical significance have not yet been investigated in CRC. MATERIAL AND METHODS We examined COX IV expression in(More)