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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
Results show that, in addition to transcriptional activation, Wnt stimulates translation and cell growth by activating the TSC-mTOR pathway, and the sequential phosphorylation of TSC2 by AMPK and GSK3 reveals a molecular mechanism of signal integration in cell growth regulation. Expand
Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb*
It is found that Bnip3, a hypoxia-inducible Bcl-2 homology 3 domain-containing protein, directly binds Rheb and inhibits the mTOR pathway, and decreases R heb GTP levels in a manner depending on the binding to RheB and the presence of the N-terminal domain. Expand
Wildtype Kras2 can inhibit lung carcinogenesis in mice
Data suggest that wildtype Kras2 has tumor suppressor activity and is frequently lost during lung tumor progression, as well as an inverse correlation between the level of wildtypes expression and extracellular signal–regulated kinase (ERK) activity in these cells. Expand
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.
Several highly mutated genes identified in the study are promising druggable targets in cancer therapy including ALK, CTNNA3, DCC, MLL3, PCDHIIX, Pik3C2B, PIK3CG and ROCK2. Expand
MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer.
The identified miRNAs hold great potential as targets for histology-specific treatment or prevention and treatment of recurrent disease, and two miRNA signatures that are highly predictive of RFS were identified. Expand
Tumor susceptibility of Rassf1a knockout mice.
The human Ras association domain family 1 (RASSF1) gene is located at 3p21.3 in an area that is believed to harbor at least one important tumor suppressor gene. The two major isoforms of RASSF1,… Expand
A Chemically Induced Model for Squamous Cell Carcinoma of the Lung in Mice
The mouse SCC described here is highly significant for preclinical studies of lung cancer chemopreventive agents because most human trials have been conducted against precancerous lesions for SCC, and can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development. Expand
Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
The prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits are demonstrated. Expand
Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas and suggest that ATB is an effective chemopreventive against mouse lung tumorigenesis. Expand
Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines.
The Pas1 locus is now sufficiently fine-mapped that candidate gene(s) for the Pas 1 locus can be characterized by positional cloning and all 27 of the known or predicted genes located in the Pas1 candidate region were characterized as possible candidate Pas genes. Expand