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Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer
TLDR
HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a, and is demonstrated to have a binding site vital for the regulation of miRNAs by HOTAIR. Expand
The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer
TLDR
Inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo and miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC. Expand
SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling
TLDR
Findings define the important role of SNORA74B in cell proliferation, cell cycle, and apoptosis of GBC, and suggest that it may serve as a novel target for GBC treatment. Expand
Forkhead Box L1 Is Frequently Downregulated in Gallbladder Cancer and Inhibits Cell Growth through Apoptosis Induction by Mitochondrial Dysfunction
TLDR
It is suggested that dysregulated FOXL1 is involved in tumorigenesis and progression of GBC and may serve as a predictor of clinical outcome or even a therapeutic target for patients with GBC. Expand
Long non‐coding RNA‐LET is a positive prognostic factor and exhibits tumor‐suppressive activity in gallbladder cancer
TLDR
The findings indicate that lncRNA‐LET may represent a prognostic marker and a potential therapeutic target for gallbladder cancer. Expand
Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer.
TLDR
GCASPC levels were significantly lower in gallbladder cancer than adjacent nontumor tissues and were associated with tumor size, American Joint Committee on Cancer tumor stage, and patient outcomes, illuminating a new basis for understanding its pathogenicity. Expand
Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway
TLDR
This study demonstrates arctigenin could induce cellular senescence in gallbladder cancer through the modulation of epidermal growth factor receptor pathway through the inhibition of the RAF-MEK-ERK signaling pathway. Expand
Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
TLDR
It is shown that NRARP is an important clinical biomarker in thyroid carcinoma and it promotes EMT induction as well as the progression of PTCs via NOTCH signaling activation. Expand
Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR‐137
TLDR
SNHG 1 upregulation was observed in CRC tissues and cell lines, which was associated with the lymph node metastasis, advanced TNM stage and poorer prognosis, and SNHG1 silencing inhibited CRC cell proliferation and migration in vitro and in vivo. Expand
The inhibitory effects of deleted in liver cancer 1 gene on gallbladder cancer growth through induction of cell cycle arrest and apoptosis
TLDR
In vitro and in vivo analysis is conducted to evaluate the inhibitory activities of DLC1 gene against GBC growth. Expand
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