Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.
- Chia-Lin Lee, F. Chang, K. Lee
- ChemistryJournal of Natural Products
- 27 February 2009
Two new phenanthrenequinones, calanquinones B and C (2 and 3) and four new 9,10-dihydrophenanthrenes, calanhydroquinones A-C (4-6) and calanphenanthrene A (7), along with five known compounds (1 and…
Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.
- Y. Usami, Yi-nan Liu, K. Lee
- Chemistry, BiologyJournal of Natural Products
- 14 February 2008
This report is the first to completely assign the (1)H NMR signals of 2, together with correction of data for 1 from prior reports, and report the complete and unambiguous assignment of 1 and 2, based on analyses of 2D NMR spectra.
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.
- M. V. B. Reddy, Chung-Ren Su, Tian-Shung Wu
- ChemistryBioorganic & Medicinal Chemistry
- 1 August 2008
Kadsufolins A-D and related cytotoxic lignans from Kadsura oblongifolia
- Zehao Huang, Yan Lu, Yi-nan Liu, K. Bastow, K. Lee, Dao-feng Chen
- Chemistry, Medicine
- 1 March 2011
Four new dibenzocyclooctane-type lignans were isolated from the roots and stems of Kadsura oblongifolia and found to show cytotoxic activities against A549, DU145, KB and HCT-8 with GI50 values of 5.1–20.0 μg/ml.
Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.
- Chia-Lin Lee, Kyoko Nakagawa-Goto, K. Lee
- Chemistry, MedicineBioorganic & Medicinal Chemistry Letters
- 1 August 2008
Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.
- Yizhou Dong, Q. Shi, Yi-nan Liu, X. Wang, K. Bastow, K. Lee
- Chemistry, BiologyJournal of Medicinal Chemistry
- 11 June 2009
A novel class of antibreast cancer agents is discovered, 2-(furan-2-yl)naphthalen-1-ol derivatives, based on an active C-ring opened model compound 5, which showed decreased cytotoxic potency but better selectivity than neo-tanshinlactone analogue 2.
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
- Yizhou Dong, Q. Shi, K. Lee
- Chemistry, BiologyJournal of Medicinal Chemistry
- 11 March 2010
Neo-tanshinlactone and its previously reported analogues, such as 2, are potent and selective in vitro antibreast cancer agents and analogue 2 showed potent activity against a ZR-75-1 Xenograft model, but not PC-3 and MDA-MB-231 xenografts, as well as high selectivity against breast cancer cell line compared with normal breast tissue-derived cell lines.
Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.
- Xiao-ming Yang, Q. Shi, K. Lee
- Chemistry, BiologyJournal of Medicinal Chemistry
- 27 August 2009
Nineteen new phenanthrene-based tylophorine analogues with various functional groups on the piperidine moiety were designed, synthesized, and evaluated for in vitro anticancer activity against four human tumor cell lines and suggested that the compounds may exert their inhibitory activity on tumor cells through inhibition of activation of both Akt and NF-kB signaling pathway.
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
- Xiao‐Feng Wang, Xing-tao Tian, Lan Xie
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 1 October 2012
Synthesis, characterization, interaction with DNA and cytotoxicity of Pd(II) and Pt(II) complexes containing pyridine carboxylic acid ligands.
- Yaguang Sun, Di Sun, V. Drǎgutan
- ChemistryDalton Transactions
- 19 February 2013
Four metal complexes synthesized under hydrothermal conditions and fully characterized by IR and (1)H-NMR spectra, elemental analysis, and X-ray single crystal diffraction analysis manifested cytotoxic specificity and a significant cancer cell inhibitory rate.
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