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Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a modifiable risk factor, and it may be feasible to delay age-related diseases as a group by modulating fundamental aging mechanisms. One such mechanism is cellular(More)
Conventional principal component analysis (PCA) performs poorly in nonlinear process monitoring due to it only can capture the linear structure of the process variables. To overcome this nonlinear problem, a new nonlinear process monitoring technique based on kernel principal component analysis (KPCA) is proposed. In order to enhance the ability of(More)
In this paper, we study the over-constrained airport gate assignment problem where the objectives are to minimize the number of ungated ights and total walking distances or connection times. We ÿrst use a greedy algorithm to minimize ungated ights. Exchange moves are employed to facilitate the use of heuristics. Simulated annealing and a hybrid of simulated(More)
A single nucleotide polymorphism (SNP) at 10q11 (rs10993994) in the 5' region of the MSMB gene was recently implicated in prostate cancer risk in two genome-wide association studies. To identify possible causal variants in the region, we genotyped 16 tagging SNPs and imputed 29 additional SNPs in approximately 65 kb genomic region at 10q11 in a Swedish(More)
In this paper we formulate a combinatorial auction brokering problem as a set packing problem and apply a simulated annealing heuristic with hybrid local moves to solve the problem. We study the existing exact and non-exact approaches to the problem and analyze the performance of those approaches. We compared our heuris-tic with the leading exact method(More)
We propose two orthogonal approaches to logarithmic cyclic shifter design. The first method, called fanout splitting, replaces multiplexers in a conventional design with demultiplexers which have two fanouts driving the shifting and non-shifting paths separately. The use of demultiplexers has a two-fold effect; it cuts the accumulated wire load on the(More)
This paper provides a comparative overview of urban transport in the world's two most populous countries: China and India. Cities in both countries are suffering from severe and worsening transport problems: air pollution, noise, traffic injuries and fatalities, congestion, parking shortages, energy use, and a lack of mobility for the poor. The urban(More)
The migration of vascular smooth muscle cells (VSMCs) plays an essential role during the development of atherosclerosis and restenosis. Extensive studies have implicated the importance of extracellular matrix (ECM)-degrading proteinases in VSMC migration. A recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin(More)
Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis. Here, we report that glucose deprivation(More)