Yi-Zhong Wang

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In order to understand the nature of the mechanisms responsible for global shape detection, we measured coherence thresholds in a 2IFC task where subjects judged which of two arrays of Gabors contained global circular structure. The stimulus was composed of an array of oriented Gabor patches positioned on a polar grid. Thresholds were obtained for different(More)
We extended a previous study (Hess et al. (1999). A deficit in strabismic amblyopia for global shape detection. Vision Research, 39, 901-914) where it was claimed that strabismic amblyopes exhibit a deficit for the detection of continuous radial frequency patterns, a task that is thought to involve global processing and in particular, a contribution of(More)
PURPOSE Recent studies suggest that a global shape-discrimination task is sensitive to neural undersampling and/or irregular sampling, but is not affected by normal aging. In this study, the ability of patients with age-related macular degeneration (AMD) to perform the shape-discrimination task was examined. METHODS Twenty patients with AMD (age range,(More)
BACKGROUND Interferon lambda 3 (IFN-λ3) is a newly identified cytokine with antiviral activity, and its single nucleotide polymorphisms are strongly associated with the treatment effectiveness and development of chronic hepatitis C virus infection. We thus examined the potential of IFN-λ3 to inhibit HIV replication and the possible mechanisms of the(More)
Contour integration plays an important role in linking local elements into global shape and the binding strength among local elements depends on both orientation and position features. The very high sensitivity reported for detecting the sinusoidal deformation of circular contours may result from the presence and concordance of both orientation and position(More)
PURPOSE Global visual integration is fundamental to shape and face recognition. Although the maturation of local visual function, such as resolution acuity, has been well documented, less is known about the changes in global visual function during development and with aging. METHODS Two hundred thirty-six normal subjects, ranging in age from 0.25- to(More)
PURPOSE In infants and toddlers, letter acuity is not a useful option, and grating acuity may underestimate the depth of strabismic amblyopia. Here, as a first step to establish the effectiveness of the paradigm as a clinical test, we assessed if radial deformation hyperacuity, known to be severely disrupted in adults with strabismic amblyopia, could be a(More)
PURPOSE To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS A subset of males (n = 24) participating in a larger natural history study of XLRS underwent(More)