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revision process of this work, an independent study reported the simultaneous generation of multiple mutations in mice 7. Our work, together with the mice work, demonstrates that it should be feasible to produce gene-targeted models in rodents and probably other mammalian species using the CRISPR-Cas systems.
Mining numerical data is a relatively diicult problem in data mining. Clustering is one of the techniques. We consider a database with numerical attributes, in which each transaction is viewed as a multi-dimensional vector. By studying the clusters formed by these vectors, we can discover certain behaviors hidden in the data. Traditional clustering(More)
Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and(More)
—Call admission control (CAC) plays a significant role in providing the desired quality of service in wireless networks. Many CAC schemes have been proposed. Analytical results for some performance metrics such as call blocking probabilities are obtained under some specific assumptions. It is observed, however, that due to the mobility, some assumptions may(More)
Spontaneous hemodynamic signals fluctuate coherently within many resting-brain functional networks not only in awake humans and lightly anesthetized primates but also in animals under deep anesthesia characterized by burst-suppression electroencephalogram (EEG) activity and unconsciousness. To understand the neural origin of spontaneous hemodynamic(More)
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete(More)
—Since the energy crisis and environmental protection are gaining increasing concerns in recent years, new research topics to devise technological solutions for energy conservation are being investigated in many scientific disciplines. Specifically, due to the rapid growth of energy consumption in ICT (Information and Communication Technologies), lot of(More)
The missing data problem greatly affects traffic analysis. In this paper, we put forward a new reliable method called probabilistic principal component analysis (PPCA) to impute the missing flow volume data based on historical data mining. First, we review the current missing data-imputation method and why it may fail to yield acceptable results in many(More)
Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the(More)