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Multiple DNA repair pathways are involved in the orderly development of neural systems at distinct stages. The homologous recombination (HR) pathway is required to resolve stalled replication forks and critical for the proliferation of progenitor cells during neural development. BCCIP is a BRCA2 and CDKN1A interacting protein implicated in HR and inhibition(More)
BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity. To understand the in vivo functions of BCCIP, we generated a conditional BCCIP knockdown transgenic mouse model using Cre-LoxP mediated RNA interference. The BCCIP knockdown embryos displayed impaired cellular proliferation and apoptosis(More)
Dysfunctions of genome caretaker genes contribute to genomic instability and tumor initiation. Because many of the caretaker genes are also essential for cell viability, permanent loss of function of these genes would prohibit further tumor progression. How essential caretaker genes contribute to tumorigenesis is not fully understood. Here, we report a(More)
In this paper, a 2.4GHz low power down-conversion mixer with high linearity for direct-conversion receivers based on a standard 0.18um CMOS technology is proposed. In the circuit design, Gilbert cell architecture and Common-Gate configuration are used. A simple buffer is applied in the IF output. Simulation results show that the mixer can operate at 2.4GHz(More)
Physalin A (PA) is an active withanolide isolated from Physalis alkekengi var. franchetii, a traditional Chinese herbal medicine named Jindenglong, which has long been used for the treatment of sore throat, hepatitis, and tumors in China. In the present study, we firstly investigated the effects of PA on proliferation and cell cycle distribution of the(More)
A 33-year-old man presented to our department for recurrent respiratory tract infections since early childhood. His physical and mental development was normal. A grade 4/6 pansystolic murmur was heard over the left sternal border. Transthoracic echocardiography (TTE) revealed a moderate sized perimembranous ventricular septal defect (PmVSD) with a 14 mm × 9(More)
Dysfunctions of genome caretaker genes contribute to genomic instability and tumor initiation. Because many of the caretaker genes are also essential for cell viability, permanent loss of function of these genes would prohibit further tumor progression. How essential caretaker genes contribute to tumorigenesis is not fully understood. Here, we report a(More)
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