Yi-Yuan Huang

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Telomerase is important in tumor initiation and cellular immortalization. Given the striking correlations between telomerase activity and proliferation capacity in tumor cells, telomerase had been considered as a potentially important molecular target in cancer therapeutics. A series of 2,7-diamidoanthraquinone were designed and synthesized. They were(More)
Telomerase is the enzymatic activity that maintains the ends of eukaryotic chromosomes. Telomerase activity is detected in most tumor cells whereas it is low or undetectable in most normal somatic cells. Expression of the telomerase catalytic component, the human telomerase reverse transcriptase (hTERT), is believed to be controlled primarily at the level(More)
In this paper, a 2.4GHz low power down-conversion mixer with high linearity for direct-conversion receivers based on a standard 0.18um CMOS technology is proposed. In the circuit design, Gilbert cell architecture and Common-Gate configuration are used. A simple buffer is applied in the IF output. Simulation results show that the mixer can operate at 2.4GHz(More)
Telomeres are the protective structures at the end of eukaryotic chromosomes. Telomerase is a ribonucleoprotein that contains both an RNA and a protein component for the maintenance of telomere length. Telomerase activity is detected in the majority of malignant tumors, but not in normal somatic cells, suggesting that telomerase reactivation is a crucial(More)
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