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Resveratrol Ameliorates the Severity of Fibrogenesis in Mice with Experimental Chronic Pancreatitis
It is suggested that resveratrol is potentially a nutraceutical for the mitigations of pancreatic fibrosis in chronic pancreatitis for which no effective therapeutic measure is currently available. Expand
Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes
The most common metastatic target proteins of ent-kauranes are MMP-2, M MP-9, VEGF, and VEGFR whereas LC-II and mTOR are key regulators to induce autophagy. Expand
Flexicaulin A, An ent-Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism
The in vitro anti-proliferative property of flexicaulin A (FA) appears to be a potent antitumor molecule, since it significantly attenuated the proliferation of human colorectal carcinoma cells in vitro and restricted the growth of corresponsive xenograft tumors in vivo without causing any adverse effects. Expand
Natural Cyclopeptides as Anticancer Agents in the Last 20 Years
Due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents and can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies. Expand