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Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer.
TLDR
This work presents a new paradigm in which hypermethylation-mediated silencing of a microRNA derepresses its oncogenic target in cancer cells, and finds a significant correlation of hypermethylated miR-129-2 with microsatellite instability and MLH1 methylation status and poor overall survival in patients. Expand
Canonical and Atypical E2Fs Regulate the Mammalian Endocycle
TLDR
In vivo evidence is provided for a direct role of E2F family members in regulating non-traditional cell cycles in mammals and coordinate the expression of a unique G2/M transcriptional program that is critical for mitosis, karyokinesis and cytokinesis. Expand
Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells
TLDR
The results suggest that ACs are responsible, at least in part, for the demethylation effects of whole black raspberries in colorectal cancers. Expand
CMS: A Web-Based System for Visualization and Analysis of Genome-Wide Methylation Data of Human Cancers
TLDR
A comprehensive collection of datasets, a variety of embedded analytic functions and extensive applications with biological and translational significance make this system powerful and unique in cancer methylation research. Expand
Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study
TLDR
Evidence is provided of the ability of BRBs to demethylate tumor suppressor genes and to modulate other biomarkers of tumor development in the human colon and rectum and the positive results with the secondary endpoints suggest that additional studies of BRB for the prevention of colorectal cancer in humans now appear warranted. Expand
Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells.
TLDR
The results suggest that the in vitro system developed in the laboratory is a valuable tool for exposure studies of BPA and other xenoestrogens in human cells and can give insight into the heritable effect of low-dose BPA inhuman cells. Expand
Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer
TLDR
The novel tumor suppressor FBXO32 is epigenetically silenced in ovarian cancer cell lines with disrupted TGF-β/SMAD4 signaling, and FBX O32 methylation status predicts survival in patients with ovarian cancer. Expand
Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development
TLDR
The first progestin-regulated miRNA expression profile is revealed and a novel role for miR-16 as a tumor suppressor in progestIn- and growth factor-induced growth in breast cancer is identified. Expand
Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats
TLDR
The results suggest that whole BRBs and their fractions alter the gut microbiota in ways that could significantly influence human health. Expand
RNA Polymerase II Binding Patterns Reveal Genomic Regions Involved in MicroRNA Gene Regulation
TLDR
A computational approach to identify the promoter region and transcription start site (TSS) of pri-microRNAs actively transcribed using genome-wide RNA Polymerase II (RPol II) binding patterns derived from ChIP-seq data is developed and applied to assess changes in microRNA transcription in steroid hormone-treated breast cancer cells. Expand
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